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Title: | Influence of elevated-CRP levelrelated polymorphisms in nonrheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis |
Author: | López Mejías, Raquel Genre, Fernanda Remuzgo Martínez, Sara González Juanatey, Carlos Robustillo Villarino, Montserrat Llorca Díaz, Javier Corrales, Alfonso Vicente, Esther F. Miranda-Filloy, José A. Magro Checa, Cesar Tejera Segura, Beatriz Ramírez Huaranga, Marco A. Pina, Trinitario Blanco, Ricardo Alegre-Sancho, Juan José Raya, Enrique Mijares, Verónica Ubilla, Begoña Mínguez Sanchez, María D. Gómez Vaquero, Carmen Balsa, Alejandro Pascual-Salcedo, Dora López Longo, Francisco J. Carreira, Patricia González Álvaro, Isidoro Rodríguez-Rodríguez, Luis Fernández Gutiérrez, Benjamín Ferraz Amaro, Iván Castañeda, Santos Martín, Javier González-Gay, Miguel A. |
Keywords: | Artritis reumatoide Aterosclerosi Rheumatoid arthritis Atherosclerosis |
Issue Date: | 18-Aug-2016 |
Publisher: | Nature Publishing Group |
Abstract: | Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/srep31979 |
It is part of: | Scientific Reports, 2016, vol. 6 |
URI: | http://hdl.handle.net/2445/126821 |
Related resource: | https://doi.org/10.1038/srep31979 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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