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Title: Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study
Author: Merritt, Melissa A.
Riboli, Elio
Murphy, Neil
Kadi, Mai
Tjønneland, Anne
Olsen, Anja
Overvad, Kim
Dossus, Laure
Dartois, Laureen
Clavel-Chapelon, Françoise
Fortner, Renée T.
Katzke, Verena Andrea
Boeing, Heiner
Trichopoulou, Antonia
Lagiou, Pagona
Trichopoulos, Dimitrios
Palli, Domenico
Sieri, Sabina
Tumino, Rosario
Sacerdote, Carlotta
Panico, Salvatore
Bueno de Mesquita, H. Bas
Peeters, Petra H. M.
Lund, Eiliv
Nakamura, Aurelie
Weiderpass, Elisabete
Quirós, J. Ramón
Agudo, Antonio
Molina Montes, Esther
Larrañaga, Nerea
Dorronsoro, Miren
Cirera, Lluís
Barricarte, Aurelio
Olsson, Åsa
Butt, Salma
Idahl, Annika
Lundin, Eva
Wareham, Nicholas J.
Key, Timothy J.
Brennan, Paul
Ferrari, Pietro
Wark, Petra A.
Norat, Teresa
Cross, Amanda J.
Gunter, Marc J.
Keywords: Càncer
Issue Date: 30-Oct-2015
Publisher: BioMed Central
Abstract: Background: Reproductive events are associated with important physiologic changes, yet little is known about how reproductive factors influence long-term health in women. Our objective was to assess the relation of reproductive characteristics with all-cause and cause-specific mortality risk. Methods: The analysis was performed within the European Investigation into Cancer and Nutrition prospective cohort study, which enrolled > 500,000 women and men from 1992 to 2000, who were residing in a given town/geographic area in 10 European countries. The current analysis included 322,972 eligible women aged 25-70 years with 99 % complete follow-up for vital status. We assessed reproductive characteristics reported at the study baseline including parity, age at the first birth, breastfeeding, infertility, oral contraceptive use, age at menarche and menopause, total ovulatory years, and history of oophorectomy/hysterectomy. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for mortality were determined using Cox proportional hazards regression models adjusted for menopausal status, body mass index, physical activity, education level, and smoking status/intensity and duration. Results: During a mean follow-up of 12.9 years, 14,383 deaths occurred. The HR (95 % CI) for risk of all-cause mortality was lower in parous versus nulliparous women (0.80; 0.76-0.84), in women who had ever versus never breastfed (0.92; 0.87-0.97), in ever versus never users of oral contraceptives (among non-smokers; 0.90; 0.86-0.95), and in women reporting a later age at menarche (>= 15 years versus < 12; 0.90; 0.85-0.96; P for trend = 0.038). Conclusions: Childbirth, breastfeeding, oral contraceptive use, and a later age at menarche were associated with better health outcomes. These findings may contribute to the development of improved strategies to promote better long-term health in women.
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It is part of: BMC Medicine, 2015, vol. 13, num. 252
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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