Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/126860
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dc.contributor.authorHuang, Ruyi-
dc.contributor.authorWei, Yongyue-
dc.contributor.authorHung, Rayjean J.-
dc.contributor.authorLiu, Geoffrey-
dc.contributor.authorSu, Li-
dc.contributor.authorZhang, Ruyang-
dc.contributor.authorZong, Xuchen-
dc.contributor.authorZhang, Zuo-Feng-
dc.contributor.authorMorgenstern, Hal-
dc.contributor.authorBrüske, Irene-
dc.contributor.authorHeinrich, Joachim-
dc.contributor.authorHong, Yun-Chul-
dc.contributor.authorKim, Jin Hee-
dc.contributor.authorCoté, Michele L.-
dc.contributor.authorWenzlaff, Angela-
dc.contributor.authorSchwartz, Ann G.-
dc.contributor.authorStucker, Isabelle-
dc.contributor.authorMcLaughlin, John R.-
dc.contributor.authorMarcus, Michael W.-
dc.contributor.authorDavies, Michael P. A.-
dc.contributor.authorLiloglou, Triantafillos-
dc.contributor.authorField, John K.-
dc.contributor.authorMatsuo, Keitaro-
dc.contributor.authorBarnett, Matt-
dc.contributor.authorThornquist, Mark D.-
dc.contributor.authorGoodman, Gary E.-
dc.contributor.authorWang, Yi-
dc.contributor.authorChen, Size-
dc.contributor.authorYang, Ping-
dc.contributor.authorDuell, Eric J.-
dc.contributor.authorAndrew, Angeline S.-
dc.contributor.authorLazarus, Philip-
dc.contributor.authorMuscat, Joshua E.-
dc.contributor.authorWoll, Penella-
dc.contributor.authorHorsman, Janet-
dc.contributor.authorTeare, M. Dawn-
dc.contributor.authorFlugelman, Anath-
dc.contributor.authorRennert, Gad-
dc.contributor.authorZhang, Yan-
dc.contributor.authorBrenner, Hermann-
dc.contributor.authorStegmaier, Christa-
dc.contributor.authorvan der Heijden, Erik H. F. M.-
dc.contributor.authorAben, Katja K.-
dc.contributor.authorKiemeney, Lambertus A. L. M.-
dc.contributor.authorBarros Dios, Juan M.-
dc.contributor.authorPérez Rios, Mónica-
dc.contributor.authorRuano Ravina, Alberto-
dc.contributor.authorCaporaso, Neil E.-
dc.contributor.authorBertazzi, Pier Alberto-
dc.contributor.authorLandi, Maria Teresa-
dc.contributor.authorDai, Juncheng-
dc.contributor.authorShen, Hongbing-
dc.contributor.authorFernandez Tardon, Guillermo-
dc.contributor.authorRodriguez Suarez, Marta-
dc.contributor.authorTardón, Adonina-
dc.contributor.authorChristiani, David C.-
dc.date.accessioned2018-12-10T14:34:54Z-
dc.date.available2018-12-10T14:34:54Z-
dc.date.issued2015-11-
dc.identifier.urihttp://hdl.handle.net/2445/126860-
dc.description.abstractBackground: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%(quit_for_5-9 years) to 89%(quit_for_>= 20 years) declined SCLC risk vs. subjects who had quit smoking <5 years. Compared with non-COPD subjects, smoking behaviors showed a significantly higher effect on SCLC risk among COPD subjects, and further, COPD patients showed a 1.86-fold higher risk of SCLC. Furthermore, smoking behaviors on SCLC risk were significantly mediated through COPD which accounted for 0.70% to 7.55% of total effects. Interpretation: This is the largest pooling study that provides improved understanding of smoking on SCLC, and further demonstrates a causal pathway through COPD that warrants further experimental study.-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.ebiom.2015.09.031-
dc.relation.ispartofEbiomedicine, 2015, vol. 2, num. 11, p. 1677-1685-
dc.relation.urihttps://doi.org/10.1016/j.ebiom.2015.09.031-
dc.rightscc by-nc-nc (c) Huang et al., 2015-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))-
dc.subject.classificationMalalties pulmonars obstructives cròniques-
dc.subject.classificationCàncer de pulmó-
dc.subject.otherChronic obstructive pulmonary diseases-
dc.subject.otherLung cancer-
dc.titleAssociated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.date.updated2018-07-25T07:56:53Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid26870794-
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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