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DC Field | Value | Language |
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dc.contributor.author | Huang, Ruyi | - |
dc.contributor.author | Wei, Yongyue | - |
dc.contributor.author | Hung, Rayjean J. | - |
dc.contributor.author | Liu, Geoffrey | - |
dc.contributor.author | Su, Li | - |
dc.contributor.author | Zhang, Ruyang | - |
dc.contributor.author | Zong, Xuchen | - |
dc.contributor.author | Zhang, Zuo-Feng | - |
dc.contributor.author | Morgenstern, Hal | - |
dc.contributor.author | Brüske, Irene | - |
dc.contributor.author | Heinrich, Joachim | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.contributor.author | Coté, Michele L. | - |
dc.contributor.author | Wenzlaff, Angela | - |
dc.contributor.author | Schwartz, Ann G. | - |
dc.contributor.author | Stucker, Isabelle | - |
dc.contributor.author | McLaughlin, John R. | - |
dc.contributor.author | Marcus, Michael W. | - |
dc.contributor.author | Davies, Michael P. A. | - |
dc.contributor.author | Liloglou, Triantafillos | - |
dc.contributor.author | Field, John K. | - |
dc.contributor.author | Matsuo, Keitaro | - |
dc.contributor.author | Barnett, Matt | - |
dc.contributor.author | Thornquist, Mark D. | - |
dc.contributor.author | Goodman, Gary E. | - |
dc.contributor.author | Wang, Yi | - |
dc.contributor.author | Chen, Size | - |
dc.contributor.author | Yang, Ping | - |
dc.contributor.author | Duell, Eric J. | - |
dc.contributor.author | Andrew, Angeline S. | - |
dc.contributor.author | Lazarus, Philip | - |
dc.contributor.author | Muscat, Joshua E. | - |
dc.contributor.author | Woll, Penella | - |
dc.contributor.author | Horsman, Janet | - |
dc.contributor.author | Teare, M. Dawn | - |
dc.contributor.author | Flugelman, Anath | - |
dc.contributor.author | Rennert, Gad | - |
dc.contributor.author | Zhang, Yan | - |
dc.contributor.author | Brenner, Hermann | - |
dc.contributor.author | Stegmaier, Christa | - |
dc.contributor.author | van der Heijden, Erik H. F. M. | - |
dc.contributor.author | Aben, Katja K. | - |
dc.contributor.author | Kiemeney, Lambertus A. L. M. | - |
dc.contributor.author | Barros Dios, Juan M. | - |
dc.contributor.author | Pérez Rios, Mónica | - |
dc.contributor.author | Ruano Ravina, Alberto | - |
dc.contributor.author | Caporaso, Neil E. | - |
dc.contributor.author | Bertazzi, Pier Alberto | - |
dc.contributor.author | Landi, Maria Teresa | - |
dc.contributor.author | Dai, Juncheng | - |
dc.contributor.author | Shen, Hongbing | - |
dc.contributor.author | Fernandez Tardon, Guillermo | - |
dc.contributor.author | Rodriguez Suarez, Marta | - |
dc.contributor.author | Tardón, Adonina | - |
dc.contributor.author | Christiani, David C. | - |
dc.date.accessioned | 2018-12-10T14:34:54Z | - |
dc.date.available | 2018-12-10T14:34:54Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126860 | - |
dc.description.abstract | Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%(quit_for_5-9 years) to 89%(quit_for_>= 20 years) declined SCLC risk vs. subjects who had quit smoking <5 years. Compared with non-COPD subjects, smoking behaviors showed a significantly higher effect on SCLC risk among COPD subjects, and further, COPD patients showed a 1.86-fold higher risk of SCLC. Furthermore, smoking behaviors on SCLC risk were significantly mediated through COPD which accounted for 0.70% to 7.55% of total effects. Interpretation: This is the largest pooling study that provides improved understanding of smoking on SCLC, and further demonstrates a causal pathway through COPD that warrants further experimental study. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.ebiom.2015.09.031 | - |
dc.relation.ispartof | Ebiomedicine, 2015, vol. 2, num. 11, p. 1677-1685 | - |
dc.relation.uri | https://doi.org/10.1016/j.ebiom.2015.09.031 | - |
dc.rights | cc by-nc-nc (c) Huang et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.classification | Càncer de pulmó | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.subject.other | Lung cancer | - |
dc.title | Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-25T07:56:53Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26870794 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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HuangRY.pdf | 548.03 kB | Adobe PDF | View/Open |
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