Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/126861
Title: Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
Author: Couch, Fergus J.
Kuchenbaecker, Karoline B.
Michailidou, Kyriaki
Mendoza-Fandino, Gustavo A.
Nord, Silje
Lilyquist, Janna
Olswold, Curtis
Hallberg, Emily
Agata, Simona
Ahsan, Habibul
Aittomäki, Kristiina
Eccles, Diana
Mulligan, Anna M.
Thompson, Deborah
Tihomirova, Laima
Dumont, Martine
Heikkinen, Tuomas
Vachon, Celine M.
Liu, Jianjun
Antoniou, Antonis C.
Haeberle, Lothar
Tapper, William
Toland, Amanda E.
Turnbull, Clare
Kar, Siddhartha
Richardson, Andrea
Benitez, Javier
Ursin, Giski
van Deurzen, Carolien H. M.
Tomlinson, Ian P.
James, Paul
Henderson, Brian E.
Frost, Debra
Olson, Janet E.
van Rensburg, Elizabeth J.
Varon-Mateeva, Raymonda
Friedman, Eitan
Karlan, Beth Y.
Bogdanova, Natalia V.
Miller, Austin
Burwinkel, Barbara
Hopper, John L.
Winqvist, Robert
Lindblom, Annika
Hollestelle, Antoinette
Cox, Angela
Yang, Xiaohong R
Yannoukakos, Drakoulis
Wang-Gohrke, Shan
Lambrechts, Diether
Sawyer, Elinor J.
Humphreys, Keith
Yao, Song
Giles, Graham G.
Lindor, Noralane
Czene, Kamila
Nussbaum, Robert L.
Díez Gibert, Orland
Ko, Yon-Dschun
Slager, Susan
Khaw, Kay-Tee
Chenevix-Trench, Georgia
Pharoah, Paul D. P.
Zheng, Wei
Manoukian, Siranoush
Szabo, Csilla I.
Konstantopoulou, Irene
Hunter, David J.
Janavicius, Ramunas
Ekici, Arif B.
Peterlongo, Paolo
Lubinski, Jan
Bojesen, Stig E.
Barrowdale, Daniel
Bolla, Manjeet K.
Bonanni, Bernardo
García Closas, Montserrat
Muranen, Taru A.
Arndt, Volker
Kosma, Veli-Matti
Anton-Culver, Hoda
Rantala, Johanna
Miron, Penelope
Daly, Mary B.
Claes, Kathleen B. M.
Damiola, Francesca
Darabi, Hatef
Osorio, Ana
Canzian, Federico
Mai, Phuong L.
Caligo, Maria A.
Olah, Edith
Ambrosone, Christine
Dunning, Alison M.
Eliassen, Heather
Ellis, Steve
Dolcetti, Riccardo
Montagna, Marco
Ding, Yuan C.
Phelan, Catherine M.
Mannermaa, Arto
Whittemore, Alice
Fasching, Peter A.
Figueroa, Jonine
Makalic, Enes
Rappaport, Christine
Haiman, Christopher A.
Tollenaar, Raem
Herzog, Josef
Pilarski, Robert
Flesch-Janys, Dieter
Gammon, Marilie D.
Singer, Christian F.
Buys, Saundra S.
Jakubowska, Anna
Ganz, Patricia A.
Gapstur, Susan M.
Fostira, Florentia
Schmutzler, Rita K.
Barkardottir, Rosa B.
Kraft, Peter
Garber, Judy
Gaudet, Mia M.
Mazoyer, Sylvie
Sinilnikova, Olga M.
Jensen, Uffe Birk
Wang, Zhaoming
Khan, Sofia
Rutgers, Emiel J.
Goldberg, Mark S.
Robson, Mark
Laitman, Yael
Goldgar, David E.
González Neira, Anna
Gerdes, Anne-Marie
Teixeira, Manuel R.
Chung, Wendy K.
Sánchez, María José
Greene, Mark H.
Olopade, Olufunmilayo I.
Lázaro García, Conxi
Zamora, M. Pilar
Lindstrom, Sara
Stenmark-Askmalm, Marie
Hamann, Ute
Beckmann, Matthias W.
Hansen, Thomas V. O.
Hart, Steven
Guénel, Pascal
Tung, Nadine
Stoppa-Lyonnet, Dominique
Santella, Regina M.
Schumacher, Fredrick
Margolin, Sara
Monteiro, Alvaro A. N.
Truong, Thérèse
John, Esther M.
Imyanitov, Evgeny N.
Jones, Michael
Kabisch, Maria
Wildiers, Hans
Hoover, Robert N.
Swerdlow, Anthony
Hooning, Maartje J.
Brauch, Hiltrud
Weiderpass, Elisabete
Lee, Eunjung
Kwong, Ava
Marchand, Loic Le
Lester, Jenny
Knight, Julia A.
Tsimiklis, Helen
Kibriya, Muhammad G.
Hall, Peter
Hogervorst, Frans B. L.
Malone, Kathleen E.
Marme, Frederik
Martens, John W. M.
Long, Jirong
Blank, Stephanie V.
Easton, Douglas F.
Tumino, Rosario
Glendon, Gord
McGuffog, Lesley
Meindl, Alfons
Teulé-Vega, Àlex
Brenner, Hermann
Poppe, Bruce
Försti, Asta
Rennert, Gad
Arun, Banu K.
Nathanson, Katherine L.
Hoya, Miguel de la
Andrulis, Irene L.
Schmidt, Marjanka K.
Neuhausen, Susan L.
Nevanlinna, Heli
Milne, Roger L.
Cross, Simon S.
Huzarski, Tomasz
Arver, Brita
Nordestgaard, Børge G.
Weitzel, Jeffrey N.
Devilee, Peter
Scott, Rodney
Gayther, Simon A.
Soucy, Penny
Carpenter, Jane
Park, Sue K.
Caldes, Trinidad
Peeters, Petra H. M.
Peissel, Bernard
Offit, Kenneth
Ehrencrona, Hans
Kristensen, Vessela
Chang-Claude, Jenny
Barile, Monica
Blomqvist, Carl
Teo, Soo-Hwang
Gronwald, Jacek
Domchek, Susan M.
Pylkäs, Katri
Isaacs, Claudine
Radice, Paolo
Rahman, Nazneen
Peto, Julian
Gabrielson, Marike
Dorfling, Cecilia M.
Chanock, Stephen J.
Cunningham, Julie M.
Healey, Sue
Foulkes, William D.
Senter, Leigha
Schmidt, Daniel F.
Sharma, Priyanka
Simard, Jacques
Godwin, Andrew K.
Rudolph, Anja
Santos-Silva, Isabel dos
Romieu, Isabelle
Ghoussaini, Maya
Beckmann, Lars
Tamimi, Rulla
Terry, Mary B.
Thomassen, Mads
Steinemann, Doris
Friebel, Tara
Southey, Melissa
Gunter, Marc
Keywords: Càncer de mama
Issue Date: 27-Apr-2016
Publisher: Nature Publishing Group
Abstract: Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 x 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for similar to 11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.
Note: Reproducció del document publicat a: https://doi.org/10.1038/ncomms11375
It is part of: Nature Communications, 2016, vol. 7
URI: http://hdl.handle.net/2445/126861
Related resource: https://doi.org/10.1038/ncomms11375
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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