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http://hdl.handle.net/2445/126874
Title: | Quantitative Trait Loci Identify Functional Noncoding Variation in Cancer |
Author: | Heyn, Holger |
Keywords: | Càncer Expressió gènica Cancer Gene expression |
Issue Date: | 3-Mar-2016 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | The interpretation of noncoding alterations in cancer genomes presents an unresolved problem in cancer studies. While the impact of somatic variations in protein-coding regions is widely accepted, noncoding aberrations are mostly considered as passenger events. However, with the advance of genome-wide profiling strategies, alterations outside the coding context entered the focus, and multiple examples highlight the role of gene deregulation as cancer-driving events. This review describes the implication of noncoding alterations in oncogenesis and provides a theoretical framework for the identification of causal somatic variants using quantitative trait loci (QTL) analysis. Assuming that functional noncoding alterations affect quantifiable regulatory processes, somatic QTL studies constitute a valuable strategy to pinpoint cancer gene deregulation. Eventually, the comprehensive identification and interpretation of coding and noncoding alterations will guide our future understanding of cancer biology. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pgen.1005826 |
It is part of: | PLoS Genetics, 2016, vol. 12, num. 3, p. e1005826 |
URI: | http://hdl.handle.net/2445/126874 |
Related resource: | https://doi.org/10.1371/journal.pgen.1005826 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
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