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Title: Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
Author: Berndt, Sonja I.
Camp, Nicola J.
Skibola, Christine F.
Vijai, Joseph
Wang, Zhaoming
Gu, Jian
Nieters, Alexandra
Kelly, Rachel S.
Smedby, Karin E.
Monnereau, Alain
Cozen, Wendy
Chang, Ellen T.
Allmer, Cristine
Hjalgrim, Henrik
Adami, Hans-Olov
Melbye, Mads
Glimelius, Bengt
Benavente, Yolanda
Glenn, Martha
Curtin, Karen
Cannon-Albright, Lisa A.
Chaffee, Kari G.
Zhi, Degui
Diver, W. Ryan
Link, Brian K.
Bracci, Paige M.
Riby, Jacques
Arnett, Donna K.
Caporaso, Neil E.
Leach, Justin M.
Holly, Elizabeth A.
Jackson, Rebecca D.
Brennan, Paul
Tinker, Lesley F.
Weinberg, J. Brice
Casabonne, Delphine
Becker, Nikolaus
Boffetta, Paolo
Chirlaque, María Dolores
Foretova, Lenka
Maynadié, Marc
MCkay, James
Staines, Anthony
Weiderpass, Elisabete
Achenbach, Sara J.
Vachon, Celine M.
Goldin, Lynn R.
Zheng, Tongzhang
Severson, Richard K.
Strom, Sara S.
Leis, Jose F.
Norman, Aaron D.
Roos, Anneclaire J. De
Morton, Lindsay M.
Bertrand, Kimberly A.
Riboli, Elio
Vineis, Paolo
Kaaks, Rudolf
Milne, Roger L.
Masala, Giovanna
Connors, Joseph M.
Vermeulen, Roel C. H.
Travis, Ruth C.
Southey, Melissa C.
Huang, Jinyan
Albanes, Demetrius
Virtamo, Jarmo
Weinstein, Stephanie
Clavel, Jacqueline
Ma, Baoshan
Holford, Theodore R.
Villano, Danylo J.
Maria, Ann
Wu, Xifeng
Turner, Jenny
Spinelli, John J.
Gascoyne, Randy D.
Giovannucci, Edward
Kraft, Peter
Kricker, Anne
Wang, Sophia S.
Ennas, Maria Grazia
Ferri, Giovanni M.
Miligi, Lucia
North, Kari E.
Liang, Liming
Cox, Angela
Crouch, Simon
Park, Ju-Hyun
Chatterjee, Nilanjan
Zhang, Yawei
Snowden, John A.
Wright, Josh
Fraumeni, Joseph F.
Offit, Kenneth
Cocco, Pierluigi
Sanjosé Llongueras, Silvia de
Cerhan, James R.
Chanock, Stephen J.
Novak, Anne J.
Yeager, Meredith
Rothman, Nathaniel
Slager, Susan L.
Lan, Qing
Teras, Lauren R.
Machado, Moara
Shanafelt, Tait D.
Brooks-Wilson, Angela R.
Hartge, Patricia
Purdue, Mark P.
Montalvan, Rebecca
Birmann, Brenda M.
Vajdic, Claire M.
Giles, Graham G.
Zeleniuch-Jacquotte, Anne
Lawrence, Charles
Conde, Lucia
Burdett, Laurie
Hutchinson, Amy
Ye, Yuanqing
Call, Timothy G.
Weiner, George J.
Kay, Neil E.
Liebow, Mark
Cunningham, Julie M.
Sala, Núria
Keywords: Leucèmia limfocítica crònica
Malalties hereditàries
Chronic lymphocytic leukemia
Genetic disorders
Issue Date: 9-Mar-2016
Publisher: Nature Publishing
Abstract: Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
Note: Reproducció del document publicat a:
It is part of: Nature Communications, 2016, vol. 7
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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