| Title: | Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| Author: | Berndt, Sonja I.
Camp, Nicola J.
Skibola, Christine F.
Vijai, Joseph
Wang, Zhaoming
Gu, Jian
Nieters, Alexandra
Kelly, Rachel S.
Smedby, Karin E.
Monnereau, Alain
Cozen, Wendy
North, Kari E.
Liang, Liming
Cox, Angela
Crouch, Simon
Park, Ju-Hyun
Chatterjee, Nilanjan
Zhang, Yawei
Snowden, John A.
Wright, Josh
Fraumeni, Joseph F.
Montalvan, Rebecca
Rothman, Nathaniel
Offit, Kenneth
Cocco, Pierluigi
Sanjosé Llongueras, Silvia de
Cerhan, James R.
Chanock, Stephen J.
Novak, Anne J.
Slager, Susan L.
Lan, Qing
Teras, Lauren R.
Birmann, Brenda M.
Machado, Moara
Shanafelt, Tait D.
Brooks-Wilson, Angela R.
Hartge, Patricia
Purdue, Mark P.
Chang, Ellen T.
Vajdic, Claire M.
Giles, Graham G.
Zeleniuch-Jacquotte, Anne
Lawrence, Charles
Conde, Lucía
Burdett, Laurie
Hutchinson, Amy
Ye, Yuanqing
Zhi, Degui
Allmer, Cristine
Call, Timothy G.
Weiner, George J.
Kay, Neil E.
Liebow, Mark
Cunningham, Julie M.
Sala Serra, Núria
Hjalgrim, Henrik
Adami, Hans-Olov
Melbye, Mads
Diver, W. Ryan
Glimelius, Bengt
Benavente, Yolanda
Glenn, Martha
Curtin, Karen
Cannon-Albright, Lisa A.
Chaffee, Kari G.
Link, Brian K.
Bracci, Paige M.
Riby, Jacques
Arnett, Donna K.
Caporaso, Neil E.
Leach, Justin M.
Holly, Elizabeth A.
Jackson, Rebecca D. J.
Severson, Richard K.
Brennan, Paul
Tinker, Lesley F.
Weinberg, J. Brice
Casabonne, Delphine
Becker, Nikolaus
Boffetta, Paolo
Chirlaque, María Dolores
Foretova, Lenka
Maynadié, Marc
McKay, James D.
Strom, Sara S.
Staines, Anthony
Weiderpass, Elisabete
Achenbach, Sara J.
Vachon, Celine M.
Goldin, Lynn R.
Zheng, Tongzhang
Leis, Jose F.
Norman, Aaron D.
Roos, Anneclaire J. De
Morton, Lindsay M.
Bertrand, Kimberly A.
Riboli, Elio
Vineis, Paolo
Kaaks, Rudolf
Turner, Jenny
Milne, Roger L.
Masala, Giovanna
Connors, Joseph M.
Vermeulen, Roel C. H.
Travis, Ruth C.
Southey, Melissa C.
Huang, Jinyan
Albanes, Demetrius
Virtamo, Jarmo
Weinstein, Stephanie J.
Spinelli, John J.
Clavel, Jacqueline
Ma, Baoshan
Holford, Theodore R.
Villano, Danylo J.
Maria, Ann
Wu, Xifeng
Gascoyne, Randy D.
Giovannucci, Edward L.
Kraft, Peter
Kricker, Anne
Wang, Sophia S.
Ennas, Maria Grazia
Ferri, Giovanni M.
Miligi, Lucia
Yeager, Meredith |
| Keywords: | Leucèmia limfocítica crònica
Malalties hereditàries
Chronic lymphocytic leukemia
Genetic disorders |
| Issue Date: | 9-Mar-2016 |
| Publisher: | Nature Publishing |
| Abstract: | Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1038/ncomms10933 |
| It is part of: | Nature Communications, 2016, vol. 7 |
| URI: | http://hdl.handle.net/2445/126875 |
| Related resource: | https://doi.org/10.1038/ncomms10933 |
| Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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