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http://hdl.handle.net/2445/126875
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DC Field | Value | Language |
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dc.contributor.author | Berndt, Sonja I. | - |
dc.contributor.author | Camp, Nicola J. | - |
dc.contributor.author | Skibola, Christine F. | - |
dc.contributor.author | Vijai, Joseph | - |
dc.contributor.author | Wang, Zhaoming | - |
dc.contributor.author | Gu, Jian | - |
dc.contributor.author | Nieters, Alexandra | - |
dc.contributor.author | Kelly, Rachel S. | - |
dc.contributor.author | Smedby, Karin E. | - |
dc.contributor.author | Monnereau, Alain | - |
dc.contributor.author | Cozen, Wendy | - |
dc.contributor.author | North, Kari E. | - |
dc.contributor.author | Liang, Liming | - |
dc.contributor.author | Cox, Angela | - |
dc.contributor.author | Crouch, Simon | - |
dc.contributor.author | Park, Ju-Hyun | - |
dc.contributor.author | Chatterjee, Nilanjan | - |
dc.contributor.author | Zhang, Yawei | - |
dc.contributor.author | Snowden, John A. | - |
dc.contributor.author | Wright, Josh | - |
dc.contributor.author | Fraumeni, Joseph F. | - |
dc.contributor.author | Montalvan, Rebecca | - |
dc.contributor.author | Rothman, Nathaniel | - |
dc.contributor.author | Offit, Kenneth | - |
dc.contributor.author | Cocco, Pierluigi | - |
dc.contributor.author | Sanjosé Llongueras, Silvia de | - |
dc.contributor.author | Cerhan, James R. | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Novak, Anne J. | - |
dc.contributor.author | Slager, Susan L. | - |
dc.contributor.author | Lan, Qing | - |
dc.contributor.author | Teras, Lauren R. | - |
dc.contributor.author | Birmann, Brenda M. | - |
dc.contributor.author | Machado, Moara | - |
dc.contributor.author | Shanafelt, Tait D. | - |
dc.contributor.author | Brooks-Wilson, Angela R. | - |
dc.contributor.author | Hartge, Patricia | - |
dc.contributor.author | Purdue, Mark P. | - |
dc.contributor.author | Chang, Ellen T. | - |
dc.contributor.author | Vajdic, Claire M. | - |
dc.contributor.author | Giles, Graham G. | - |
dc.contributor.author | Zeleniuch-Jacquotte, Anne | - |
dc.contributor.author | Lawrence, Charles | - |
dc.contributor.author | Conde, Lucía | - |
dc.contributor.author | Burdett, Laurie | - |
dc.contributor.author | Hutchinson, Amy | - |
dc.contributor.author | Ye, Yuanqing | - |
dc.contributor.author | Zhi, Degui | - |
dc.contributor.author | Allmer, Cristine | - |
dc.contributor.author | Call, Timothy G. | - |
dc.contributor.author | Weiner, George J. | - |
dc.contributor.author | Kay, Neil E. | - |
dc.contributor.author | Liebow, Mark | - |
dc.contributor.author | Cunningham, Julie M. | - |
dc.contributor.author | Sala Serra, Núria | - |
dc.contributor.author | Hjalgrim, Henrik | - |
dc.contributor.author | Adami, Hans-Olov | - |
dc.contributor.author | Melbye, Mads | - |
dc.contributor.author | Diver, W. Ryan | - |
dc.contributor.author | Glimelius, Bengt | - |
dc.contributor.author | Benavente, Yolanda | - |
dc.contributor.author | Glenn, Martha | - |
dc.contributor.author | Curtin, Karen | - |
dc.contributor.author | Cannon-Albright, Lisa A. | - |
dc.contributor.author | Chaffee, Kari G. | - |
dc.contributor.author | Link, Brian K. | - |
dc.contributor.author | Bracci, Paige M. | - |
dc.contributor.author | Riby, Jacques | - |
dc.contributor.author | Arnett, Donna K. | - |
dc.contributor.author | Caporaso, Neil E. | - |
dc.contributor.author | Leach, Justin M. | - |
dc.contributor.author | Holly, Elizabeth A. | - |
dc.contributor.author | Jackson, Rebecca D. J. | - |
dc.contributor.author | Severson, Richard K. | - |
dc.contributor.author | Brennan, Paul | - |
dc.contributor.author | Tinker, Lesley F. | - |
dc.contributor.author | Weinberg, J. Brice | - |
dc.contributor.author | Casabonne, Delphine | - |
dc.contributor.author | Becker, Nikolaus | - |
dc.contributor.author | Boffetta, Paolo | - |
dc.contributor.author | Chirlaque, María Dolores | - |
dc.contributor.author | Foretova, Lenka | - |
dc.contributor.author | Maynadié, Marc | - |
dc.contributor.author | McKay, James D. | - |
dc.contributor.author | Strom, Sara S. | - |
dc.contributor.author | Staines, Anthony | - |
dc.contributor.author | Weiderpass, Elisabete | - |
dc.contributor.author | Achenbach, Sara J. | - |
dc.contributor.author | Vachon, Celine M. | - |
dc.contributor.author | Goldin, Lynn R. | - |
dc.contributor.author | Zheng, Tongzhang | - |
dc.contributor.author | Leis, Jose F. | - |
dc.contributor.author | Norman, Aaron D. | - |
dc.contributor.author | Roos, Anneclaire J. De | - |
dc.contributor.author | Morton, Lindsay M. | - |
dc.contributor.author | Bertrand, Kimberly A. | - |
dc.contributor.author | Riboli, Elio | - |
dc.contributor.author | Vineis, Paolo | - |
dc.contributor.author | Kaaks, Rudolf | - |
dc.contributor.author | Turner, Jenny | - |
dc.contributor.author | Milne, Roger L. | - |
dc.contributor.author | Masala, Giovanna | - |
dc.contributor.author | Connors, Joseph M. | - |
dc.contributor.author | Vermeulen, Roel C. H. | - |
dc.contributor.author | Travis, Ruth C. | - |
dc.contributor.author | Southey, Melissa C. | - |
dc.contributor.author | Huang, Jinyan | - |
dc.contributor.author | Albanes, Demetrius | - |
dc.contributor.author | Virtamo, Jarmo | - |
dc.contributor.author | Weinstein, Stephanie J. | - |
dc.contributor.author | Spinelli, John J. | - |
dc.contributor.author | Clavel, Jacqueline | - |
dc.contributor.author | Ma, Baoshan | - |
dc.contributor.author | Holford, Theodore R. | - |
dc.contributor.author | Villano, Danylo J. | - |
dc.contributor.author | Maria, Ann | - |
dc.contributor.author | Wu, Xifeng | - |
dc.contributor.author | Gascoyne, Randy D. | - |
dc.contributor.author | Giovannucci, Edward L. | - |
dc.contributor.author | Kraft, Peter | - |
dc.contributor.author | Kricker, Anne | - |
dc.contributor.author | Wang, Sophia S. | - |
dc.contributor.author | Ennas, Maria Grazia | - |
dc.contributor.author | Ferri, Giovanni M. | - |
dc.contributor.author | Miligi, Lucia | - |
dc.contributor.author | Yeager, Meredith | - |
dc.date.accessioned | 2018-12-11T10:47:25Z | - |
dc.date.available | 2018-12-11T10:47:25Z | - |
dc.date.issued | 2016-03-09 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126875 | - |
dc.description.abstract | Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/ncomms10933 | - |
dc.relation.ispartof | Nature Communications, 2016, vol. 7 | - |
dc.relation.uri | https://doi.org/10.1038/ncomms10933 | - |
dc.rights | cc by (c) Berndt et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Leucèmia limfocítica crònica | - |
dc.subject.classification | Malalties hereditàries | - |
dc.subject.other | Chronic lymphocytic leukemia | - |
dc.subject.other | Genetic disorders | - |
dc.title | Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-25T07:52:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26956414 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
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BerndtSI.pdf | 1.04 MB | Adobe PDF | View/Open |
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