Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/126875
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dc.contributor.authorBerndt, Sonja I.-
dc.contributor.authorCamp, Nicola J.-
dc.contributor.authorSkibola, Christine F.-
dc.contributor.authorVijai, Joseph-
dc.contributor.authorWang, Zhaoming-
dc.contributor.authorGu, Jian-
dc.contributor.authorNieters, Alexandra-
dc.contributor.authorKelly, Rachel S.-
dc.contributor.authorSmedby, Karin E.-
dc.contributor.authorMonnereau, Alain-
dc.contributor.authorCozen, Wendy-
dc.contributor.authorChang, Ellen T.-
dc.contributor.authorAllmer, Cristine-
dc.contributor.authorHjalgrim, Henrik-
dc.contributor.authorAdami, Hans-Olov-
dc.contributor.authorMelbye, Mads-
dc.contributor.authorGlimelius, Bengt-
dc.contributor.authorBenavente, Yolanda-
dc.contributor.authorGlenn, Martha-
dc.contributor.authorCurtin, Karen-
dc.contributor.authorCannon-Albright, Lisa A.-
dc.contributor.authorChaffee, Kari G.-
dc.contributor.authorZhi, Degui-
dc.contributor.authorDiver, W. Ryan-
dc.contributor.authorLink, Brian K.-
dc.contributor.authorBracci, Paige M.-
dc.contributor.authorRiby, Jacques-
dc.contributor.authorArnett, Donna K.-
dc.contributor.authorCaporaso, Neil E.-
dc.contributor.authorLeach, Justin M.-
dc.contributor.authorHolly, Elizabeth A.-
dc.contributor.authorJackson, Rebecca D.-
dc.contributor.authorBrennan, Paul-
dc.contributor.authorTinker, Lesley F.-
dc.contributor.authorWeinberg, J. Brice-
dc.contributor.authorCasabonne, Delphine-
dc.contributor.authorBecker, Nikolaus-
dc.contributor.authorBoffetta, Paolo-
dc.contributor.authorChirlaque, María Dolores-
dc.contributor.authorForetova, Lenka-
dc.contributor.authorMaynadié, Marc-
dc.contributor.authorMCkay, James-
dc.contributor.authorStaines, Anthony-
dc.contributor.authorWeiderpass, Elisabete-
dc.contributor.authorAchenbach, Sara J.-
dc.contributor.authorVachon, Celine M.-
dc.contributor.authorGoldin, Lynn R.-
dc.contributor.authorZheng, Tongzhang-
dc.contributor.authorSeverson, Richard K.-
dc.contributor.authorStrom, Sara S.-
dc.contributor.authorLeis, Jose F.-
dc.contributor.authorNorman, Aaron D.-
dc.contributor.authorRoos, Anneclaire J. De-
dc.contributor.authorMorton, Lindsay M.-
dc.contributor.authorBertrand, Kimberly A.-
dc.contributor.authorRiboli, Elio-
dc.contributor.authorVineis, Paolo-
dc.contributor.authorKaaks, Rudolf-
dc.contributor.authorMilne, Roger L.-
dc.contributor.authorMasala, Giovanna-
dc.contributor.authorConnors, Joseph M.-
dc.contributor.authorVermeulen, Roel C. H.-
dc.contributor.authorTravis, Ruth C.-
dc.contributor.authorSouthey, Melissa C.-
dc.contributor.authorHuang, Jinyan-
dc.contributor.authorAlbanes, Demetrius-
dc.contributor.authorVirtamo, Jarmo-
dc.contributor.authorWeinstein, Stephanie-
dc.contributor.authorClavel, Jacqueline-
dc.contributor.authorMa, Baoshan-
dc.contributor.authorHolford, Theodore R.-
dc.contributor.authorVillano, Danylo J.-
dc.contributor.authorMaria, Ann-
dc.contributor.authorWu, Xifeng-
dc.contributor.authorTurner, Jenny-
dc.contributor.authorSpinelli, John J.-
dc.contributor.authorGascoyne, Randy D.-
dc.contributor.authorGiovannucci, Edward-
dc.contributor.authorKraft, Peter-
dc.contributor.authorKricker, Anne-
dc.contributor.authorWang, Sophia S.-
dc.contributor.authorEnnas, Maria Grazia-
dc.contributor.authorFerri, Giovanni M.-
dc.contributor.authorMiligi, Lucia-
dc.contributor.authorNorth, Kari E.-
dc.contributor.authorLiang, Liming-
dc.contributor.authorCox, Angela-
dc.contributor.authorCrouch, Simon-
dc.contributor.authorPark, Ju-Hyun-
dc.contributor.authorChatterjee, Nilanjan-
dc.contributor.authorZhang, Yawei-
dc.contributor.authorSnowden, John A.-
dc.contributor.authorWright, Josh-
dc.contributor.authorFraumeni, Joseph F.-
dc.contributor.authorOffit, Kenneth-
dc.contributor.authorCocco, Pierluigi-
dc.contributor.authorSanjosé Llongueras, Silvia de-
dc.contributor.authorCerhan, James R.-
dc.contributor.authorChanock, Stephen J.-
dc.contributor.authorNovak, Anne J.-
dc.contributor.authorYeager, Meredith-
dc.contributor.authorRothman, Nathaniel-
dc.contributor.authorSlager, Susan L.-
dc.contributor.authorLan, Qing-
dc.contributor.authorTeras, Lauren R.-
dc.contributor.authorMachado, Moara-
dc.contributor.authorShanafelt, Tait D.-
dc.contributor.authorBrooks-Wilson, Angela R.-
dc.contributor.authorHartge, Patricia-
dc.contributor.authorPurdue, Mark P.-
dc.contributor.authorMontalvan, Rebecca-
dc.contributor.authorBirmann, Brenda M.-
dc.contributor.authorVajdic, Claire M.-
dc.contributor.authorGiles, Graham G.-
dc.contributor.authorZeleniuch-Jacquotte, Anne-
dc.contributor.authorLawrence, Charles-
dc.contributor.authorConde, Lucia-
dc.contributor.authorBurdett, Laurie-
dc.contributor.authorHutchinson, Amy-
dc.contributor.authorYe, Yuanqing-
dc.contributor.authorCall, Timothy G.-
dc.contributor.authorWeiner, George J.-
dc.contributor.authorKay, Neil E.-
dc.contributor.authorLiebow, Mark-
dc.contributor.authorCunningham, Julie M.-
dc.contributor.authorSala, Núria-
dc.date.accessioned2018-12-11T10:47:25Z-
dc.date.available2018-12-11T10:47:25Z-
dc.date.issued2016-03-09-
dc.identifier.urihttp://hdl.handle.net/2445/126875-
dc.description.abstractChronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherNature Publishing-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/ncomms10933-
dc.relation.ispartofNature Communications, 2016, vol. 7-
dc.relation.urihttps://doi.org/10.1038/ncomms10933-
dc.rightscc by (c) Berndt et al., 2016-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subject.classificationLeucèmia limfocítica crònica-
dc.subject.classificationMalalties hereditàries-
dc.subject.otherChronic lymphocytic leukemia-
dc.subject.otherGenetic disorders-
dc.titleMeta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.date.updated2018-07-25T07:52:02Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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