Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/126880
Title: Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study
Author: Chuang, Shu-Chun
Boeing, Heiner
Vollset, Stein Emil
Midttun, Øivind
Ueland, Per Magne
Bueno de Mesquita, H. Bas
Lajous, Martin
Fagherazzi, Guy
Boutron-Ruault, Marie-Christine
Kaaks, Rudolf
Küehn, Tilman
Pischon, Tobias
Drogan, Dagmar
Tjønneland, Anne
Overvad, Kim
Quirós, J. Ramón
Agudo, Antonio
Molina Montes, Esther
Dorronsoro, Miren
Huerta, José María
Barricarte, Aurelio
Khaw, Kay-Tee
Wareham, Nicholas J.
Travis, Ruth C.
Trichopoulou, Antonia
Lagiou, Pagona
Trichopoulos, Dimitrios
Masala, Giovanna
Agnoli, Claudia
Tumino, Rosario
Mattiello, Amalia
Peeters, Petra H. M.
Weiderpass, Elisabete
Palmqvist, Richard
Ljuslinder, Ingrid
Gunter, Marc
Lu, Yunxia
Cross, Amanda J.
Riboli, Elio
Vineis, Paolo
Aleksandrova, Krasimira
Keywords: Hiperlipèmia
Neopterina
Síndrome metabòlica
Hyperlipidemia
Neopterin
Metabolic syndrome
Issue Date: 25-Feb-2016
Publisher: BioMed Central
Abstract: Background: Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43). Conclusions: These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.
Note: Reproducció del document publicat a: https://doi.org/10.1186/s12979-016-0059-y
It is part of: Immunity & Ageing, 2016, vol. 13, num. 5
URI: http://hdl.handle.net/2445/126880
Related resource: https://doi.org/10.1186/s12979-016-0059-y
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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