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http://hdl.handle.net/2445/127015| Title: | Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst |
| Author: | Salomó i Prat, Ernest Gallen Ortiz, Albert Sciortino, Giuseppe Ujaque, Gregori Grabulosa, Arnald Lledós, Agustí (Lledós i Falcó) Riera i Escalé, Antoni Verdaguer i Espaulella, Xavier |
| Keywords: | Catàlisi asimètrica Lligands Hidrogenació Enantioselective catalysis Ligands Hydrogenation |
| Issue Date: | 26-Nov-2018 |
| Publisher: | American Chemical Society |
| Abstract: | A novel cationic [IrH(THF)(P,N)(imine)] [BArF] catalyst contg. a P-stereogenic MaxPHOX ligand is described for the direct asym. hydrogenation of N-Me and N-alkyl imines. This is the first catalytic system to attain high enantioselectivity (up to 94% ee) in this type of transformation. The labile THF ligand allows for effective activation and reactivity, even at low temps. D. functional theory calcns. allowed the rationalization of the stereochem. course of the reaction. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1021/jacs.8b11547 |
| It is part of: | Journal of the American Chemical Society, 2018, vol. 140, p. 16967-16970 |
| URI: | http://hdl.handle.net/2445/127015 |
| Related resource: | https://doi.org/10.1021/jacs.8b11547 |
| ISSN: | 0002-7863 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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|---|---|---|---|---|
| 683625.pdf | 530.66 kB | Adobe PDF | View/Open |
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