Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/127085
Title: Acrylamide and glycidamide hemoglobin adducts and epithelial ovarian cancer: a nested case-control study in nonsmoking postmenopausal women from the EPIC cohort
Author: Obón Santacana, Mireia
Luján Barroso, Leila
Travis, Ruth C.
Freisling, Heinz
Ferrari, Pietro
Severi, Gianluca
Baglietto, Laura
Boutron-Ruault, Marie-Christine
Fortner, Reneé T.
Ose, Jennifer
Boeing, Heiner
Menéndez, Virginia
Sánchez Cantalejo, Emilio
Chamosa, Saioa
Huerta Castaño, José María
Ardanaz, Eva
Khaw, Kay-Tee
Wareham, Nicholas J.
Merritt, Melissa A.
Gunter, Marc J.
Trichopoulou, Antonia
Papatesta, Eleni Maria
Klinaki, Eleni
Saieva, Calogero
Tagliabue, Giovanna
Tumino, Rosario
Sacerdote, Carlotta
Mattiello, Amalia
Bueno de Mesquita, H. Bas
Peeters, Petra H. M.
Onland Moret, N.Charlotte
Idahl, Annika
Lundin, Eva
Weiderpass, Elisabete
Vesper, Huber W.
Riboli, Elio
Duell, Eric J.
Keywords: Càncer d'ovari
Hemoglobina
Marcadors bioquímics
Ovarian cancer
Hemoglobin
Biochemical markers
Issue Date: Jan-2016
Publisher: American Association for Cancer Research
Abstract: Background: Acrylamide was classified as 'probably carcinogenic to humans (group 2A)' by the International Agency for Research on Cancer. Epithelial ovarian cancer (EOC) is the fourth cause of cancer mortality in women. Five epidemiological studies have evaluated the association between EOC risk and dietary acrylamide intake assessed using food frequency questionnaires, and one nested case-control study evaluated hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA) and EOC risk; the results of these studies were inconsistent. Methods: A nested case-control study in nonsmoking postmenopausal women (334 cases, 417 controls) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Unconditional logistic regression models were used to estimate ORs and 95% confidence intervals (CI) for the association between HbAA, HbGA, HbAA+HbGA, and HbGA/HbAA and EOC and invasive serous EOC risk. Results: No overall associations were observed between biomarkers of acrylamide exposure analyzed in quintiles and EOC risk; however, positive associations were observed between some middle quintiles of HbGA and HbAA+HbGA. Elevated but non-statistically significant ORs for serous EOC were observed for HbGA and HbAA+HbGA (ORQ5vsQ1, 1.91; 95% CI, 0.96-3.81 and ORQ5vsQ1, 1.90; 95% CI, 0.94-3.83, respectively); however, no linear dose-response trends were observed. Conclusion: This EPIC nested case-control study failed to observe a clear association between biomarkers of acrylamide exposure and the risk of EOC or invasive serous EOC. Impact: It is unlikely that dietary acrylamide exposure increases ovarian cancer risk; however, additional studies with larger sample size should be performed to exclude any possible association with EOC risk.
Note: Versió postprint del document publicat a: https://doi.org/10.1158/1055-9965.EPI-15-0822
It is part of: Cancer Epidemiology Biomarkers & Prevention, 2016, vol. 25, num. 1, p. 127-134
URI: http://hdl.handle.net/2445/127085
Related resource: https://doi.org/10.1158/1055-9965.EPI-15-0822
ISSN: 1055-9965
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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