Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/127103
Title: The effect of a mediterranean diet on the incidence of cataract surgery
Author: García Layana, Alfredo
Ciufo, Gianfranco
Toledo Atucha, Estefanía
Martínez-González, Miguel Ángel, 1957-
Corella Piquer, Dolores
Fitó Colomer, Montserrat
Estruch Riba, Ramon
Gómez Gracia, Enrique
Fiol Sala, Miguel
Lapetra, José
Serra Majem, Lluís
Pintó Sala, Xavier
Portillo, María P.
Sorlí, José V.
Bulló, Mònica
Vinyoles, Ernest
Sala Vila, Aleix
Ros Rahola, Emilio
Salas Salvadó, Jordi
Arós, Fernando
Keywords: Cuina mediterrània
Cirurgia de cataractes
Antioxidants
Cataractes
Mediterranean cooking
Cataract surgery
Antioxidants
Cataract
Issue Date: 3-May-2017
Publisher: MDPI
Abstract: Background: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. Methods: We included 5802 men and women (age range: 55-80 years) from the Prevencion con Dieta Mediterronea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. Results: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. Conclusions: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery.
Note: Reproducció del document publicat a: https://doi.org/10.3390/nu9050453
It is part of: Nutrients, 2017, vol. 9, num. 5
URI: http://hdl.handle.net/2445/127103
Related resource: https://doi.org/10.3390/nu9050453
ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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