Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/127180
Title: Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy
Author: Kovacs, Gabor G.
Ferrer, Isidro (Ferrer Abizanda)
Grinberg, Lea T.
Alafuzoff, Irina
Attems, Johannes
Budka, Herbert
Cairns, Nigel J.
Crary, John F.
Duyckaerts, Charles
Ghetti, Bernardino
Halliday, Glenda M.
Ironside, James W.
Love, Seth
Mackenzie, Ian R.
Muñoz, David G.
Murray, Melissa E.
Nelson, Peter T.
Takahashi, Hitoshi
Trojanowski, John Q.
Ansorge, Olaf
Arzberger, Thomas
Baborie, Atik
Beach, Thomas G.
Bigio, Eileen H.
Bodi, Istvan
Dugger, Brittany N.
Feany, Mel
Gelpi, Ellen
Gentleman, Stephen M.
Giaccone, Giorgio
Hatanpaa, Kimmo J.
Heale, Richard
Hof, Patrick R.
Hofer, Monika
Hortobágyi, Tibor
Jellinger, Kurt
Jicha, Gregory A.
Ince, Paul
Kofler, Julia
Kövari, Enikö
Bieniek, Kevin F.
Kril, Jillian J.
Mann, David M.
Matej, Radoslav
McKee, Ann C.
Milenkovic, Ivan
Montine, Thomas J.
Murayama, Shigeo
Lee, Edward B.
Rodriguez, Roberta D.
Rozemüller, Annemieke
Schneider, Julie A.
Schultz, Christian
Seeley, William
Seilhean, Danielle
Smith, Colin
Tagliavini, Fabrizio
Takao, Masaki
Thal, Dietmar Rudolf
Toledo, Jon B.
Tolnay, Markus
Troncoso, Juan C.
Vinters, Harry V.
Weis, Serge
Wharton, Stephen B.
White III, Charles L.
McLean, Catriona
Rahimi, Jasmin
Wisniewski, Thomas
Woulfe, John M.
Yamada, Masahito
Dickson, Dennis W.
Keywords: Envelliment cerebral
Astròcits
Malalties neurodegeneratives
Aging brain
Astrocytes
Neurodegenerative diseases
Issue Date: Jan-2016
Publisher: Springer Verlag
Abstract: Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.
Note: Versió postprint del document publicat a: https://doi.org/10.1007/s00401-015-1509-x
It is part of: Acta Neuropathologica, 2016, vol. 131, num. 1, p. 87-102
URI: http://hdl.handle.net/2445/127180
Related resource: https://doi.org/10.1007/s00401-015-1509-x
ISSN: 0001-6322
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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