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Title: Allosterism and signal transfer in DNA
Author: Balaceanu, Alexandra
Pérez, Alberto
Dans, Pablo D.
Orozco López, Modesto
Keywords: ADN
Dinàmica molecular
Molecular dynamics
Issue Date: 14-Jun-2018
Publisher: Oxford University Press
Abstract: We analysed the basic mechanisms of signal transmission in DNA and the origins of the allostery exhibited by systems such as the ternary complex BAMHI-DNA-GRDBD. We found that perturbation information generated by a primary protein binding event travels as a wave to distant regions of DNA following a hopping mechanism. However, such a structural perturbation is transient and does not lead to permanent changes in the DNA geometry and interaction properties at the secondary binding site. The BAMHI-DNA-GRDBD allosteric mechanism does not occur through any traditional models: direct (protein-protein), indirect (reorganization of the secondary site) readout or solvent-release. On the contrary, it is generated by a subtle and less common entropy-mediated mechanism, which might have an important role to explain other DNA-mediated cooperative effects.
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It is part of: Nucleic Acids Research, 2018, vol. 46, num. 15, p. 7554-7565
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ISSN: 0305-1048
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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