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http://hdl.handle.net/2445/127216
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DC Field | Value | Language |
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dc.contributor.author | Balaceanu, Alexandra | - |
dc.contributor.author | Pérez, Alberto | - |
dc.contributor.author | Dans, Pablo D. | - |
dc.contributor.author | Orozco López, Modesto | - |
dc.date.accessioned | 2019-01-11T18:03:12Z | - |
dc.date.available | 2019-01-11T18:03:12Z | - |
dc.date.issued | 2018-06-14 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | http://hdl.handle.net/2445/127216 | - |
dc.description.abstract | We analysed the basic mechanisms of signal transmission in DNA and the origins of the allostery exhibited by systems such as the ternary complex BAMHI-DNA-GRDBD. We found that perturbation information generated by a primary protein binding event travels as a wave to distant regions of DNA following a hopping mechanism. However, such a structural perturbation is transient and does not lead to permanent changes in the DNA geometry and interaction properties at the secondary binding site. The BAMHI-DNA-GRDBD allosteric mechanism does not occur through any traditional models: direct (protein-protein), indirect (reorganization of the secondary site) readout or solvent-release. On the contrary, it is generated by a subtle and less common entropy-mediated mechanism, which might have an important role to explain other DNA-mediated cooperative effects. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/nar/gky549 | - |
dc.relation.ispartof | Nucleic Acids Research, 2018, vol. 46, num. 15, p. 7554-7565 | - |
dc.relation.uri | https://doi.org/10.1093/nar/gky549 | - |
dc.rights | cc-by-nc (c) Balaceanu, Alexandra et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | ADN | - |
dc.subject.classification | Dinàmica molecular | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Lligands | - |
dc.subject.other | DNA | - |
dc.subject.other | Molecular dynamics | - |
dc.subject.other | Proteins | - |
dc.subject.other | Ligands | - |
dc.title | Allosterism and signal transfer in DNA | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 682925 | - |
dc.date.updated | 2019-01-11T18:03:12Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/676556/EU//MuG | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29905860 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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682925.pdf | 6.29 MB | Adobe PDF | View/Open |
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