Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/127394
Title: | A multifunctional toolkit for target-directed cancer therapy |
Author: | Terrazas Martínez, Montserrat Sánchez, Dani Battistini, Federica Villegas, Núria Brun-Heath, Isabelle Orozco López, Modesto |
Keywords: | Càncer de mama Cèl·lules canceroses Breast cancer Cancer cells |
Issue Date: | 14-Dec-2018 |
Publisher: | Royal Society of Chemistry |
Abstract: | Here we present 2shRNA, a shRNA-based nanobinder, which can simultaneously attack two therapeutic targets involved in drug resistance pathways and can additionally bind accessory molecules such as cell targeting peptides or fluorophores. We create 2shRNAs designed to specifically kill HER2+ breast cancer cells in the absence of a transfecting agent. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1039/C8CC08823C |
It is part of: | Chemical Communications, 2018 |
URI: | http://hdl.handle.net/2445/127394 |
Related resource: | http://dx.doi.org/10.1039/C8CC08823C |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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Manuscript_Terrazas_Orozco_rev2_Dec5_2018.pdf | 2.86 MB | Adobe PDF | View/Open |
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