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http://hdl.handle.net/2445/127545
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DC Field | Value | Language |
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dc.contributor.author | Graus Ribas, Francesc | - |
dc.contributor.author | Saiz Hinarejos, Albert | - |
dc.contributor.author | Lai, Marina | - |
dc.contributor.author | Bruna, Jordi | - |
dc.contributor.author | López, Francisca | - |
dc.contributor.author | Sabater, Lidia | - |
dc.contributor.author | Blanco, Yolanda | - |
dc.contributor.author | Rey, María Jesús | - |
dc.contributor.author | Ribalta Farrés, Teresa María | - |
dc.contributor.author | Dalmau Obrador, Josep | - |
dc.date.accessioned | 2019-01-23T10:53:58Z | - |
dc.date.available | 2019-01-23T10:53:58Z | - |
dc.date.issued | 2008-09-16 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | http://hdl.handle.net/2445/127545 | - |
dc.description.abstract | Objective: To report the frequency and type of antibodies against neuronal surface antigens (NSA-ab) in limbic encephalitis (LE). Methods: Analysis of clinical features, neuropathologic findings, and detection of NSA-ab using immunochemistry on rat tissue and neuronal cultures in a series of 45 patients with paraneoplastic (23) or idiopathic (22) LE. Results: NSA-ab were identified in 29 patients (64%; 12 paraneoplastic, 17 idiopathic). Thirteen patients had voltage-gated potassium channels (VGKC)-ab, 11 novel NSA (nNSA)-ab, and 5 NMDA receptor (NMDAR)-ab. nNSA-ab did not identify a common antigen and were more frequent in paraneoplastic than idiopathic LE (39% vs 9%; p = 0.03). When compared with VGKC-ab or NMDAR-ab, the nNSA associated more frequently with intraneuronal antibodies (11% vs 73%; p = 0.001). Of 12 patients (9 nNSA-ab, 2 VGKC-ab, 1 NMDAR-ab) with paraneoplastic LE and NSA-ab, concomitant intraneuronal antibodies occurred in 9 (75%). None of these 12 patients improved with immunotherapy. The autopsy of three of them showed neuronal loss, microgliosis, and cytotoxic T cell infiltrates in the hippocampus and amygdala. These findings were compatible with a T-cell mediated neuronal damage. In contrast, 13 of 17 (76%) patients with idiopathic LE and NSA-ab (8 VGKC-ab, 4 NMDAR-ab, 1 nNSA-ab) and 1 of 5 (20%) without antibodies had clinical improvement (p = 0.04). Conclusions: In paraneoplastic limbic encephalitis (LE), novel antibodies against neuronal surface antigens (nNSA-ab) occur frequently, coexist with antibodies against intracellular antigens, and these cases are refractory to immunotherapy. In idiopathic LE, the likelihood of improvement is significantly higher in patients with NSA-ab than in those without antibodies. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Lippincott, Williams & Wilkins. Wolters Kluwer Health | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1212/01.wnl.0000325917.48466.55 | - |
dc.relation.ispartof | Neurology, 2008, vol. 71, num. 12, p. 930-936 | - |
dc.relation.uri | https://doi.org/10.1212/01.wnl.0000325917.48466.55 | - |
dc.rights | (c) American Academy of Neurology, 2008 | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Encefalitis | - |
dc.subject.classification | Immunoglobulines | - |
dc.subject.classification | Immunoteràpia | - |
dc.subject.other | Encephalitis | - |
dc.subject.other | Immunoglobulins | - |
dc.subject.other | Immunotheraphy | - |
dc.title | Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associations | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 612250 | - |
dc.date.updated | 2019-01-23T10:53:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 18794496 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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612250.pdf | 2.33 MB | Adobe PDF | View/Open |
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