Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/127611
Title: Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature.
Author: Salaverria, Itziar
Zettl, Andreas
Beà, Sílvia
Moreno Aguado, Víctor
Valls, Joan
Hartmann, Elena
Ott, German
Wright, George
Lopez Guillermo, Armando
Chan, Wing C.
Weisenburger, Dennis D.
Gascoyne, Randy D.
Grogan, Thomas M.
Delabie, Jan
Jaffe, Elaine S.
Montserrat, Emili
Muller Hermelink, Hans Konrad
Rosenwald, Andreas
Campo Güerri, Elias
Staudt, Louis M.
Keywords: Limfomes
Pronòstic mèdic
Expressió gènica
Lymphomas
Prognosis
Gene expression
Issue Date: 1-Apr-2007
Publisher: American Society of Clinical Oncology
Abstract: Purpose To compare the genetic relationship between cyclin D1 - positive and cyclin D1 - negative mantle cell lymphomas (MCLs) and to determine whether specific genetic alterations may add prognostic information to survival prediction based on the proliferation signature of MCLs. Patients and Methods Seventy-one cyclin D1 - positive and six cyclin D1 - negative MCLs previously characterized by gene expression profiling were examined by comparative genomic hybridization (CGH). Results Cyclin D1 - negative MCLs were genetically characterized by gains of 3q, 8q, and 15q, and losses of 1p, 8p23- pter, 9p21- pter, 11q21- q23, and 13q that were also the most common alterations in conventional MCLs. Parallel analysis of CGH aberrations and locus-specific gene expression profiles in cyclin D1 - positive patients showed that chromosomal imbalances had a substantial impact on the expression levels of the genes located in the altered regions. The analysis of prognostic factors revealed that the proliferation signature, the number of chromosomal aberrations, gains of 3q, and losses of 8p, 9p, and 9q predicted survival of MCL patients. A multivariate analysis showed that the gene expression-based proliferation signature was the strongest predictor for shorter survival. However, 3q gains and 9q losses provided prognostic information that was independent of the proliferative activity. Conclusion Cyclin D1 - positive and - negative MCLs share the same secondary genetic aberrations, supporting the concept that they correspond to the same genetic entity. The integration of genetic information on chromosome 3q and 9q alterations into a proliferation signature-based model may improve the ability to predict survival in patients with MCL.
Note: Reproducció del document publicat a: https://doi.org/10.1200/JCO.2006.08.4251
It is part of: Journal of Clinical Oncology, 2007, vol. 25, num. 10, p. 1216-1222
URI: http://hdl.handle.net/2445/127611
Related resource: https://doi.org/10.1200/JCO.2006.08.4251
ISSN: 0732-183X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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