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Title: | Critical comparison of shake-flask, potentiometric and chromatographic methods for lipophilicity evaluation (log Po/w) of neutral, acidic, basic, amphoteric, and zwitterionic drugs |
Author: | Port, Ariadna Bordas, Magda Enrech, Raquel Pascual, Rosalía Rosés Pascual, Martí Ràfols Llach, Clara Subirats i Vila, Xavier Bosch, Elisabeth |
Keywords: | Lipofília Cromatografia de líquids Potenciòmetres Concentració dels ions d'hidrogen Lipophilicity Liquid chromatography Potentiometer Hydrogen-ion concentration |
Issue Date: | 10-Jul-2018 |
Publisher: | Elsevier B.V. |
Abstract: | In the present study three different procedures have been compared for the determination of the lipophilicity of the unionized species (log Po/w) of neutral, acidic, basic, amphoteric, and zwitterionic drugs. Shake-flask, potentiometric and chromatographic approaches have been assayed in a set of 66 representative compounds in different phases of advanced development. An excellent equivalence has been found between log Po/w values obtained by shake-flask and potentiometry, while the chromatographic approach is less accurate but very convenient for screening purposes when a high-throughput is required. In the case of zwitterionic and amphoteric compounds, either for shake-flask and chromatographic methods, the pH has to be accurately selected in order to ensure the compound to be in its neutral form. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.ejps.2018.07.010 |
It is part of: | European Journal of Pharmaceutical Sciences, 2018, vol. 122, p. 331-340 |
URI: | http://hdl.handle.net/2445/127667 |
Related resource: | https://doi.org/10.1016/j.ejps.2018.07.010 |
ISSN: | 0928-0987 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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