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http://hdl.handle.net/2445/127737| Title: | Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds |
| Author: | Solé Arjó, Daniel Mariani, Francesco Bennasar Fèlix, M. Lluïsa Fernández Cadenas, Israel |
| Keywords: | Pal·ladi (Element químic) Catàlisi Síntesi orgànica Complexitat computacional Química organometàl·lica Palladium Catalysis Organic synthesis Computational complexity Organometallic chemistry |
| Issue Date: | 15-Apr-2016 |
| Publisher: | Wiley-VCH |
| Abstract: | A palladium‐catalyzed carbene insertion into C(sp3)−H bonds leading to pyrrolidines was developed. The coupling reaction can be catalyzed by both Pd0 and PdII, is regioselective, and shows a broad functional group tolerance. This reaction is the first example of palladium‐catalyzed C(sp3)−C(sp3) bond assembly starting from diazocarbonyl compounds. DFT calculations revealed that this direct C(sp3)−H bond functionalization reaction involves an unprecedented concerted metalation-deprotonation step. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1002/anie.201602020 |
| It is part of: | Angewandte Chemie-International Edition, 2016, vol. 55, num. 22, p. 6467-6470 |
| URI: | http://hdl.handle.net/2445/127737 |
| Related resource: | https://doi.org/10.1002/anie.201602020 |
| ISSN: | 1433-7851 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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|---|---|---|---|---|
| 659135.pdf | 605.7 kB | Adobe PDF | View/Open |
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