Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/127810
Title: | Exploring Partners for the Domino α‐Arylation/Michael Addition Reaction Leading to Tetrahydroisoquinolines |
Author: | Solé Arjó, Daniel Pérez Janer, Ferran García-Rodeja Navarro, Yago Fernández Cadenas, Israel |
Keywords: | Pal·ladi (Element químic) Catàlisi Sulfamides Teoria del funcional de densitat Síntesi orgànica Palladium Catalysis Sulfonamides Density functionals Organic synthesis |
Issue Date: | 3-Jan-2017 |
Publisher: | Wiley-VCH |
Abstract: | Sulfonates, sulfonamides, and phosphonates have proven useful nucleophiles for palladium‐catalyzed intramolecular α‐arylation reactions leading to tetrahydroisoquinolines. Although the sulfonate α‐arylation reaction can be successfully combined in a domino process with a broad range of Michael acceptors, only vinyl sulfones can be used in Michael additions when starting from sulfonamides. No domino process was developed with the phosphonate derivative. DFT calculations were carried out to gain more insights into the experimental differences observed in the reactions involving these substrates. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/ejoc.201601300 |
It is part of: | European Journal of Organic Chemistry, 2017, vol. 2017, num. 4, p. 799-805 |
URI: | http://hdl.handle.net/2445/127810 |
Related resource: | https://doi.org/10.1002/ejoc.201601300 |
ISSN: | 1434-193X |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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667423.pdf | 1.09 MB | Adobe PDF | View/Open |
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