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http://hdl.handle.net/2445/127967
Title: | Risk model for prostate cancer using environmental and genetic factors in the spanish multi-case-control (MCC) study |
Author: | Gómez Acebo, Inés Dierssen Sotos, Trinidad Fernández Navarro, Pablo Palazuelos-Calderón, Camilo Moreno Aguado, Víctor Aragonès Sanz, Núria Castaño-Vinyals, Gemma Jiménez Moleón, José Juan Ruiz Cerdá, José L. Pérez Gómez, Beatriz Ruiz-Dominguez, José Manuel Alonso-Molero, Jéssica Pollán, Marina Kogevinas, Manolis Llorca Díaz, Javier |
Keywords: | Càncer de pròstata Espanya Homes Genètica Medi ambient Factors de risc en les malalties Prostate cancer Spain Men Genetics Natural environment Risk factors in diseases |
Issue Date: | 21-Aug-2017 |
Publisher: | Nature Publishing Group |
Abstract: | Prostate cancer (PCa) is the second most common cancer among men worldwide. Its etiology remains largely unknown compared to other common cancers. We have developed a risk stratification model combining environmental factors with family history and genetic susceptibility. 818 PCa cases and 1,006 healthy controls were compared. Subjects were interviewed on major lifestyle factors and family history. Fifty-six PCa susceptibility SNPs were genotyped. Risk models based on logistic regression were developed to combine environmental factors, family history and a genetic risk score. In the whole model, compared with subjects with low risk (reference category, decile 1), those carrying an intermediate risk (decile 5) had a 265% increase in PCa risk (OR = 3.65, 95% CI 2.26 to 5.91). The genetic risk score had an area under the ROC curve (AUROC) of 0.66 (95% CI 0.63 to 0.68). When adding the environmental score and family history to the genetic risk score, the AUROC increased by 0.05, reaching 0.71 (95% CI 0.69 to 0.74). Genetic susceptibility has a stronger risk value of the prediction that modifiable risk factors. While the added value of each SNP is small, the combination of 56 SNPs adds to the predictive ability of the risk model. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-09386-9 |
It is part of: | Scientific Reports, 2017, vol. 7, p. 8994 |
URI: | http://hdl.handle.net/2445/127967 |
Related resource: | https://doi.org/10.1038/s41598-017-09386-9 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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