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http://hdl.handle.net/2445/127968
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DC Field | Value | Language |
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dc.contributor.author | Ibáñez Sanz, Gemma | - |
dc.contributor.author | Díez Villanueva, Anna | - |
dc.contributor.author | Alonso Aguado, Maria Henar | - |
dc.contributor.author | Rodríguez Moranta, Francisco | - |
dc.contributor.author | Pérez Gómez, Beatriz | - |
dc.contributor.author | Bustamante Pineda, Mariona | - |
dc.contributor.author | Martín Sánchez, Vicente | - |
dc.contributor.author | Llorca Díaz, Javier | - |
dc.contributor.author | Amiano, Pilar | - |
dc.contributor.author | Ardanaz, Eva | - |
dc.contributor.author | Tardón, Adonina | - |
dc.contributor.author | Jiménez Moleón, José Juan | - |
dc.contributor.author | Peiró Pérez, Rosana | - |
dc.contributor.author | Alguacil, Juan | - |
dc.contributor.author | Navarro Sánchez, Carmen | - |
dc.contributor.author | Guinó, Elisabet | - |
dc.contributor.author | Binefa i Rodríguez, Gemma | - |
dc.contributor.author | Fernández Navarro, Pablo | - |
dc.contributor.author | Espinosa Cardiel, Ana | - |
dc.contributor.author | Dávila Batista, Verónica | - |
dc.contributor.author | Molina de la Torre, Antonio José | - |
dc.contributor.author | Palazuelos-Calderón, Camilo | - |
dc.contributor.author | Aragonès Sanz, Núria | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.contributor.author | Pollán, Marina | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.date.accessioned | 2019-02-06T13:16:53Z | - |
dc.date.available | 2019-02-06T13:16:53Z | - |
dc.date.issued | 2017-02-24 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/127968 | - |
dc.description | Aquest article conté una errata annexada | - |
dc.description.abstract | Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep43263 | - |
dc.relation.ispartof | Scientific Reports, 2017, vol. 7, p. 43263 | - |
dc.relation.uri | https://doi.org/10.1038/srep43263 | - |
dc.rights | cc-by (c) Ibáñez Sanz, Gemma et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Espanya | - |
dc.subject.classification | Genètica | - |
dc.subject.classification | Epidemiologia | - |
dc.subject.classification | Influència del medi ambient en l'home | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Spain | - |
dc.subject.other | Genetics | - |
dc.subject.other | Epidemiology | - |
dc.subject.other | Environmental effects on human beings | - |
dc.subject.other | Risk factors in diseases | - |
dc.title | Risk model for colorectal cancer in spanish population using environmental and genetic factors: results from the MCC-Spain study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 671476 | - |
dc.date.updated | 2019-02-06T13:16:53Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28233817 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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671476.pdf | 967.03 kB | Adobe PDF | View/Open | |
671476_errata.pdf | 110.83 kB | Adobe PDF | View/Open |
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