Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/127974
Title: Perinatal and childhood factors and risk of breast cancer subtypes in adulthood
Author: Lope, Virginia
García Esquinas, Esther
Pérez Gómez, Beatriz
Altzibar, Jone M.
Gracia Lavedan, Esther
Ederra, María
Molina de la Torre, Antonio José
Llorca, Francisco Javier
Tardón, Adonina
Moreno Aguado, Víctor
Bayo, Juan
Salas Trejo, Dolores
Marcos Gragera, Rafael
Pumarega, José
Dierssen Sotos, Trinidad
Barrio Lera, Juan Pablo
Miguel Medina, M. A. Concepción de
Tusquets, Ignasi
Amiano, Pilar
Boldo, Elena
Kogevinas, Manolis
Aragonés, Nuria
Castaño Vinyals, Gemma
Pollán, Marina
Keywords: Càncer de mama
Infància
Breast cancer
Childhood
Issue Date: 1-Feb-2016
Publisher: Elsevier
Abstract: BACKGROUND: Accumulated exposure to hormones and growth factors during early life may influence the future risk of breast cancer (BC). This study examines the influence of childhood-related, socio-demographic and anthropometric variables on BC risk, overall and by specific pathologic subtypes. METHODS: This is a case-control study where 1539 histologically-confirmed BC cases (23-85 years) and 1621 population controls, frequency matched by age, were recruited in 10 Spanish provinces. Perinatal and childhood-related characteristics were directly surveyed by trained staff. The association with BC risk, globally and according to menopausal status and pathologic subtypes, was evaluated using logistic and multinomial regression models, adjusting for tumor specific risk factors. RESULTS: Birth characteristics were not related with BC risk. However, women with high socioeconomic level at birth presented a decreased BC risk (OR=0.45; 95% CI=0.29-0.70), while those whose mothers were aged over 39 years at their birth showed an almost significant excess risk of hormone receptor positive tumors (HR+) (OR=1.35; 95% CI=0.99-1.84). Women who were taller than their girl mates before puberty showed increased postmenopausal BC risk (OR=1.26; 95% CI=1.03-1.54) and increased HR+ BC risk (OR=1.26; 95% CI=1.04-1.52). Regarding prepubertal weight, while those women who were thinner than average showed higher postmenopausal BC risk (OR=1.46; 95% CI=1.20-1.78), associated with HR+ tumors (OR=1.34; 95% CI=1.12-1.61) and with triple negative tumors (OR=1.56; 95% CI=1.03-2.35), those who were heavier than average presented lower premenopausal BC risk (OR=0.64; 95% CI=0.46-0.90) and lower risk of epidermal growth factor receptor positive tumors (OR=0.61; 95% CI=0.40-0.93). CONCLUSION: These data reflect the importance of hormones and growth factors in the early stages of life, when the mammary gland is in development and therefore more vulnerable to proliferative stimuli.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.canep.2015.11.004
It is part of: Cancer Epidemiology, 2016, vol. 40, p. 22-30
URI: http://hdl.handle.net/2445/127974
Related resource: https://doi.org/10.1016/j.canep.2015.11.004
ISSN: 1877-7821
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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