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Title: Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study
Author: Andrianopoulos, Vasileios
Celli, Bartolome R.
Franssen, Frits M.E.
Pinto-Plata, Victor M.
Calverley, Peter M. A.
Vanfleteren, Lowie E. G. W.
Vogiatzis, Ioannis
Vestbo, Jørgen
Agustí García-Navarro, Àlvar
Bakke, Per S.
Rennard, Stephen I.
MacNee, William
Tal-Singer, Ruth
Yates, Julie C.
Wouters, Emiel
Spruit, Martijn
Keywords: Malalties pulmonars obstructives cròniques
Chronic obstructive pulmonary diseases
Issue Date: Oct-2016
Publisher: Elsevier B.V.
Abstract: Exercise-induced oxygen desaturation (EID) is related to mortality in patients with chronic obstructive pulmonary disease (COPD). We investigated: (1) the prevalence of EID; (2) the relative-weight of several physiological determinants of EID including pulmonary emphysema, and (3) the relationship of EID with certain patients' clinical characteristics. Data from 2050 COPD patients (age: 63.3 ± 7.1years; FEV1: 48.7 ± 15.7%pred.) were analyzed. The occurrence of EID (SpO2post ≤88%) at the six-minute walking test (6MWT) was investigated in association with emphysema quantified by computed-tomography (QCT), and several clinical characteristics. 435 patients (21%) exhibited EID. Subjects with EID had more QCT-emphysema, lower exercise capacity and worse health-status (BODE, ADO indexes) compared to non-EID. Determinant of EID were obesity (BMI≥30 kg/m2), impaired FEV1 (≤44%pred.), moderate or worse emphysema, and low SpO2 at rest (≤93%). Linear regression indicated that each 1-point increase on the ADO-score independently elevates odds ratio (≤1.5fold) for EID.About one in five COPD patients in the ECLIPSE cohort present EID. Advanced emphysema is associated with EID. In addition, obesity, severe airflow limitation, and low resting oxygen saturation increase the risk for EID. Patients with EID in GOLD stage II have higher odds to have moderate or worse emphysema compared those with EID in GOLD stage III-IV. Emphysematous patients with high ADO-score should be monitored for EID.
Note: Versió postprint del document publicat a:
It is part of: Respiratory Medicine, 2016, vol. 119, p. 87-95
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ISSN: 0954-6111
Appears in Collections:Articles publicats en revistes (Medicina)

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