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Title: DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control
Author: Kretzmer, Helene
Bernhart, Stephan H.
Wang, Wei
Haake, Andrea
Weniger, Marc A.
Bergmann, Anke K.
Betts, Matthew J.
Carrillo de Santa Pau, Enrique
Doose, Gero
Gutwein, Jana
Richter, Julia
Hovestadt, Volker
Huang, Bingding
Rico, Daniel
Jühling, Frank
Kolarova, Julia
Lu, Qianhao
Otto, Christian
Wagener, Rabea
Arnolds, Judith
Burkhardt, Birgit
Claviez, Alexander
Drexler, Hans G.
Eberth, Sonja
Eils, Roland
Flicek, Paul
Haas, Siegfried
Hummel, Michael
Karsch, Dannis
Kerstens, Hinrik H. D.
Klapper, Wolfram
Kreuz, Markus
Lawerenz, Chris
Martín-Subero, José Ignacio
Lenze, Dido
Loeffler, Markus
López, Cristina
MacLeod, Roderick A. F.
Martens, Joost H. A.
Kulis, Marta
Möller, Peter
Nage, Inga
Picelli, Simone
Vater, Inga
Rohde, Marius
Rosenstiel, Philip
Rosolowski, Maciej
Russell, Robert B.
Schilhabel, Markus
Schlesner, Matthias
Stadler, Peter F.
Szczepanowski, Monika
Trümper, Lorenz
Stunnenberg, Hendrik G.
Küppers, Ralf
Ammerpohl, Ole
Lichter, Peter
Siebert, Reiner
Hoffmann, Steve
Radlwimmer, Bernhard
ICGC MMML-Seq project
Keywords: Cèl·lules B
B cells
Issue Date: 5-Oct-2015
Publisher: Nature Publishing Group
Abstract: Although Burkitt lymphomas and follicular lymphomas both have features of germinal center B cells, they are biologically and clinically quite distinct. Here we performed whole-genome bisulfite, genome and transcriptome sequencing in 13 IG-MYC translocation-positive Burkitt lymphoma, nine BCL2 translocation-positive follicular lymphoma and four normal germinal center B cell samples. Comparison of Burkitt and follicular lymphoma samples showed differential methylation of intragenic regions that strongly correlated with expression of associated genes, for example, genes active in germinal center dark-zone and light-zone B cells. Integrative pathway analyses of regions differentially methylated in Burkitt and follicular lymphomas implicated DNA methylation as cooperating with somatic mutation of sphingosine phosphate signaling, as well as the TCF3-ID3 and SWI/SNF complexes, in a large fraction of Burkitt lymphomas. Taken together, our results demonstrate a tight connection between somatic mutation, DNA methylation and transcriptional control in key B cell pathways deregulated differentially in Burkitt lymphoma and other germinal center B cell lymphomas.
Note: Versió postprint del document publicat a:
It is part of: Nature Genetics, 2015, vol. 47, num. 11, p. 1316-1325
Related resource:
ISSN: 1061-4036
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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