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Title: Association between mental disorders and subsequent adult onset asthma
Author: Alonso, Jordi
Jonge, Peter de
Lim, Carmen C. W.
Aguilar Gaxiola, Sergio
Bruffaerts, Ronny
Caldas de Almeida, Jose Miguel
Liu, Zhaorui
Neill, Siobhan O'
Stein, Dan J.
Viana, Maria Carmen
Al-Hamzawi, Ali Obaid
Angermeyer, Matthias C.
Borges, Guilherme
Ciutan, Marius
Girolamo, Giovanni de
Fiestas, Fabian
Haro Abad, Josep Maria
Hu, Chiyi
Kessler, Ronald C.
Lépine, Jean Pierre
Levinson, Daphna
Nakamura, Yosikazu
Posada Villa, Jose
Wojtyniak, Bogdan J.
Scott, Kate M.
Keywords: Malalties mentals
Mental illness
Issue Date: Dec-2014
Publisher: Elsevier Ltd
Abstract: Associations between asthma and anxiety and mood disorders are well established, but little is known about their temporal sequence. We examined associations between a wide range of DSM-IV mental disorders with adult onset of asthma and whether observed associations remain after mental comorbidity adjustments. METHODS: During face-to-face household surveys in community-dwelling adults (n = 52,095) of 19 countries, the WHO Composite International Diagnostic Interview retrospectively assessed lifetime prevalence and age at onset of 16 DSM-IV mental disorders. Asthma was assessed by self-report of physician's diagnosis together with age of onset. Survival analyses estimated associations between first onset of mental disorders and subsequent adult onset asthma, without and with comorbidity adjustment. RESULTS: 1860 adult onset (21 years+) asthma cases were identified, representing a total of 2,096,486 person-years of follow up. After adjustment for comorbid mental disorders several mental disorders were associated with subsequent adult asthma onset: bipolar (OR = 1.8; 95%CI 1.3-2.5), panic (OR = 1.4; 95%CI 1.0-2.0), generalized anxiety (OR = 1.3; 95%CI 1.1-1.7), specific phobia (OR = 1.3; 95%CI 1.1-1.6); post-traumatic stress (OR = 1.5; 95%CI 1.1-1.9); binge eating (OR = 1.8; 95%CI 1.2-2.9) and alcohol abuse (OR = 1.5; 95%CI 1.1-2.0). Mental comorbidity linearly increased the association with adult asthma. The association with subsequent asthma was stronger for mental disorders with an early onset (before age 21). CONCLUSIONS: A wide range of temporally prior mental disorders are significantly associated with subsequent onset of asthma in adulthood. The extent to which asthma can be avoided or improved among those with early mental disorders deserves study.
Note: Versió postprint del document publicat a:
It is part of: Journal of Psychiatric Research, 2014, vol. 59, p. 179-188
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ISSN: 0022-3956
Appears in Collections:Articles publicats en revistes (Medicina)

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