Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/128140
Title: The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing
Author: Swerdlow, Steven H.
Kuzu, Isinsu
Dogan, Ahmet
Dirnhofer, Stephan
Chan, John K. C.
Sander, Birgitta
Ott, German
Xerri, Luc
Quintanilla Martinez, Leticia
Campo Güerri, Elias
Keywords: Cèl·lules B
Limfomes
Leucèmia limfocítica crònica
B cells
Lymphomas
Chronic lymphocytic leukemia
Issue Date: 1-Jan-2016
Publisher: Springer Verlag
Abstract: Plasmacytic differentiation may occur in almost all small B cell lymphomas (SBLs), although it varies from being uniformly present (as in lymphoplasmacytic lymphoma (LPL)) to very uncommon (as in mantle cell lymphomas (MCLs)). The discovery of MYD88 L265P mutations in the vast majority of LPLs has had a major impact on the study of these lymphomas. Review of the cases contributed to the 2014 European Association for Haematopathology/Society for Hematopathology slide workshop illustrated how mutational testing has helped refine the diagnostic criteria for LPL, emphasizing the importance of identifying a clonal monotonous lymphoplasmacytic population and highlighting how LPL can still be diagnosed with extensive nodal architectural effacement, very subtle plasmacytic differentiation, follicular colonization, or uncommon phenotypes such as CD5 or CD10 expression. MYD88 L265P mutations were found in 11/11 LPL cases versus only 2 of 28 other SBLs included in its differential diagnosis. Mutational testing also helped to exclude other cases that would have been considered LPL in the past. The workshop also highlighted how plasmacytic differentiation can occur in chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, SOX11 negative MCL, and particularly in marginal zone lymphomas, all of which can cause diagnostic confusion with LPL. The cases also highlighted the difficulty in distinguishing lymphomas with marked plasmacytic differentiation from plasma cell neoplasms. Some SBLs with plasmacytic differentiation can be associated with amyloid, other immunoglobulin deposition, or crystal-storing histiocytosis, which may obscure the underlying neoplasm. Finally, although generally indolent, LPL may transform, with the workshop cases suggesting a role for TP53 abnormalities.
Note: Versió postprint del document publicat a: https://doi.org/10.1007/s00428-015-1858-9
It is part of: Virchows Archiv-An International Journal of Pathology, 2016, vol. 468, num. 3, p. 259-275
Related resource: https://doi.org/10.1007/s00428-015-1858-9
URI: http://hdl.handle.net/2445/128140
ISSN: 0945-6317
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)

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