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http://hdl.handle.net/2445/128168
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DC Field | Value | Language |
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dc.contributor.author | Altamirano, José | - |
dc.contributor.author | Miquel Morera, Rosa | - |
dc.contributor.author | Katoonizadeh, Aezam | - |
dc.contributor.author | Abraldes, Juan G. | - |
dc.contributor.author | Duarte Rojo, Andrés | - |
dc.contributor.author | Louvet, Alexandre | - |
dc.contributor.author | Augustin, Salvador | - |
dc.contributor.author | Mookerjee, Rajeshwar P. | - |
dc.contributor.author | Michelena, Javier | - |
dc.contributor.author | Smyrk, Thomas C. | - |
dc.contributor.author | Buob, David | - |
dc.contributor.author | Leteurtre, Emmanuelle | - |
dc.contributor.author | Rincón, Diego | - |
dc.contributor.author | Ruiz, Pablo | - |
dc.contributor.author | García Pagán, Juan Carlos | - |
dc.contributor.author | Guerrero Marquez, Carmen | - |
dc.contributor.author | Jones, Patricia D. | - |
dc.contributor.author | Barritt, A.S 4th. | - |
dc.contributor.author | Arroyo, Vicente | - |
dc.contributor.author | Bruguera i Cortada, Miquel, 1942- | - |
dc.contributor.author | Bañares, Rafael | - |
dc.contributor.author | Ginès i Gibert, Pere | - |
dc.contributor.author | Caballeria Rovira, Joan | - |
dc.contributor.author | Roskams, Tania | - |
dc.contributor.author | Nevens, Frederick | - |
dc.contributor.author | Jalan, Rajiv | - |
dc.contributor.author | Mathurin, Philippe | - |
dc.contributor.author | Shah, Vijay H. | - |
dc.contributor.author | Bataller Alberola, Ramón | - |
dc.date.accessioned | 2019-02-12T12:50:48Z | - |
dc.date.available | 2019-02-12T12:50:48Z | - |
dc.date.issued | 2014-01-15 | - |
dc.identifier.issn | 0016-5085 | - |
dc.identifier.uri | http://hdl.handle.net/2445/128168 | - |
dc.description.abstract | BACKGROUND & AIMS: There is no histologic classification system to determine prognoses of patients with alcoholic hepatitis (AH). We identified histologic features associated with disease severity and created a histologic scoring system to predict short-term (90-day) mortality. METHODS: We analyzed data from 121 patients admitted to the Liver Unit (Hospital Clinic, Barcelona, Spain) from January 2000 to January 2008 with features of AH and developed a histologic scoring system to determine the risk of death using logistic regression. The system was tested and updated in a test set of 96 patients from 5 academic centers in the United States and Europe, and a semiquantitative scoring system called the Alcoholic Hepatitis Histologic Score (AHHS) was developed. The system was validated in an independent set of 109 patients. Interobserver agreement was evaluated by weighted κ statistical analysis. RESULTS: The degree of fibrosis, degree of neutrophil infiltration, type of bilirubinostasis, and presence of megamitochondria were independently associated with 90-day mortality. We used these 4 parameters to develop the AHHS to identify patients with a low (0-3 points), moderate (4-5 points), or high (6-9 points) risk of death within 90 days (3%, 19%, and 51%, respectively; P < .0001). The AHHS estimated 90-day mortality in the training and test sets with an area under the receiver operating characteristic value of 0.77 (95% confidence interval, 0.71-0.83). Interrater agreement values were 0.65 for fibrosis, 0.86 for bilirubinostasis, 0.60 for neutrophil infiltration, and 0.46 for megamitochondria. Interestingly, the type of bilirubinostasis predicted the development of bacterial infections. CONCLUSIONS: We identified histologic features associated with the severity of AH and developed a patient classification system that might be used in clinical decision making. | - |
dc.format.extent | 22 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1053/j.gastro.2014.01.018 | - |
dc.relation.ispartof | Gastroenterology, 2014, vol. 146, num. 5, p. 1231-1239 | - |
dc.relation.uri | https://doi.org/10.1053/j.gastro.2014.01.018 | - |
dc.rights | (c) AGA Institute, 2014 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Hepatitis | - |
dc.subject.classification | Alcoholisme | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.classification | Malalties del fetge | - |
dc.subject.other | Hepatitis | - |
dc.subject.other | Alcoholism | - |
dc.subject.other | Prognosis | - |
dc.subject.other | Liver diseases | - |
dc.title | A histologic scoring system for prognosis of patients with Alcoholic hepatitis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 638865 | - |
dc.date.updated | 2019-02-12T12:50:48Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24440674 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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638865.pdf | 480.23 kB | Adobe PDF | View/Open |
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