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Title: Synthesis of a-chlorolactams by cyanoborohydride-mediated radical cyclization of trichloroacetamides
Author: Coussanes, Guilhem
Jakobi, Harald
Lindell, Stephen
Bonjoch i Sesé, Josep
Keywords: Lactames
Radicals (Química)
Síntesi orgànica
Radicals (Chemistry)
Organic synthesis
Issue Date: 16-May-2018
Publisher: Wiley-VCH
Abstract: A cyanoborohydride-promoted radical cyclization methodology has been developed to access α-chlorolactams in a simple and efficient way, using NaBH3CN and trichloroacetamides easily available from allylic and homoallylic secondary amines. This methodology allowed the synthesis of a library of αchlorolactams (mono and bicyclic), which were tested for herbicidal activity, trans-3-chloro-4-methyl-1-(3-trifluoromethyl)phenyl-2-pyrrolidinone being the most active.
Note: Versió postprint del document publicat a:
It is part of: Chemistry-A European Journal, 2018, vol. 24, num. 32, p. 8151-8156
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ISSN: 0947-6539
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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