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http://hdl.handle.net/2445/128365
Title: | Synthesis of Normorphans through an Efficient Intramolecular Carbamoylation of Ketones |
Author: | Diaba, Faïza Montiel Achong, Juan Andrés Serban, Georgeta Bonjoch i Sesé, Josep |
Keywords: | Cetones Amines Síntesi orgànica Reaccions químiques Ketones Amines Organic synthesis Chemical reactions |
Issue Date: | 21-Jan-2015 |
Publisher: | American Chemical Society |
Abstract: | An unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine treatment and exploited to develop a new synthesis of normophans from 4-amidocyclohexanones. The reaction involves an unprecedented intramolecular haloform-type reaction of trichloroacetamides promoted by enamines (generated in situ from ketones) as counter-reagents. The methodology was applied to the synthesis of compounds embodying the 6-azabicyclo[3.2.1]octane framework. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acs.orglett.5b01832 |
It is part of: | Organic Letters, 2015, vol. 2015, num. 17, p. 3860-3863 |
URI: | http://hdl.handle.net/2445/128365 |
Related resource: | https://doi.org/10.1021/acs.orglett.5b01832 |
ISSN: | 1523-7060 |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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