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Title: Herpes simplex virus encephalitis is a trigger of brain autoimmunity
Author: Armangué, Thaís
Leypoldt, Frank
Málaga, Ignacio
Raspall Chaure, Miquel
Marti, Itxaso
Nichter, Charles
Pugh, John
Vicente-Rasoamalala, Mónica
Lafuente-Hidalgo, Miguel
Macaya Ruiz, Alfons
Ke, Michael
Titulaer, Maarten J.
Höftberger, Romana
Sheriff, Heather
Glaser, Carol
Dalmau Obrador, Josep
Keywords: Encefalitis
Malalties cerebrals
Herpesvirus diseases
Brain diseases
Issue Date: Feb-2014
Publisher: Wiley-Liss
Abstract: In 5 prospectively diagnosed patients with relapsing post-herpes simplex encephalitis (HSE), N-methyl-D-aspartate receptor (NMDAR) antibodies were identified. Antibody synthesis started 1 to 4 weeks after HSE, preceding the neurological relapse. Three of 5 patients improved postimmunotherapy, 1 spontaneously, and 1 has started to improve. Two additional patients with NMDAR antibodies, 9 with unknown neuronal surface antibodies, and 1 with NMDAR and unknown antibodies, were identified during retrospective assessment of 34 HSE patients; the frequency of autoantibodies increased over time (serum, p=0.004; cerebrospinal fluid, p=0.04). The 3 retrospectively identified NMDAR antibody-positive patients also had evidence of relapsing post-HSE. Overall, these findings indicate that HSE triggers NMDAR antibodies and potentially other brain autoimmunity.
Note: Versió postprint del document publicat a:
It is part of: Annals of Neurology, 2013, vol. 75, num. 2, p. 317-323
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ISSN: 0364-5134
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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