Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/129163
Title: | Herpes simplex virus encephalitis is a trigger of brain autoimmunity |
Author: | Armangué, Thaís Leypoldt, Frank Málaga, Ignacio Raspall Chaure, Miquel Marti, Itxaso Nichter, Charles Pugh, John Vicente-Rasoamalala, Mónica Lafuente-Hidalgo, Miguel Macaya Ruiz, Alfons Ke, Michael Titulaer, Maarten J. Höftberger, Romana Sheriff, Heather Glaser, Carol Dalmau Obrador, Josep |
Keywords: | Encefalitis Herpes Autoimmunitat Malalties cerebrals Encephalitis Herpesvirus diseases Autoimmunity Brain diseases |
Issue Date: | Feb-2014 |
Publisher: | Wiley-Liss |
Abstract: | In 5 prospectively diagnosed patients with relapsing post-herpes simplex encephalitis (HSE), N-methyl-D-aspartate receptor (NMDAR) antibodies were identified. Antibody synthesis started 1 to 4 weeks after HSE, preceding the neurological relapse. Three of 5 patients improved postimmunotherapy, 1 spontaneously, and 1 has started to improve. Two additional patients with NMDAR antibodies, 9 with unknown neuronal surface antibodies, and 1 with NMDAR and unknown antibodies, were identified during retrospective assessment of 34 HSE patients; the frequency of autoantibodies increased over time (serum, p=0.004; cerebrospinal fluid, p=0.04). The 3 retrospectively identified NMDAR antibody-positive patients also had evidence of relapsing post-HSE. Overall, these findings indicate that HSE triggers NMDAR antibodies and potentially other brain autoimmunity. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/ana.24083 |
It is part of: | Annals of Neurology, 2013, vol. 75, num. 2, p. 317-323 |
URI: | http://hdl.handle.net/2445/129163 |
Related resource: | https://doi.org/10.1002/ana.24083 |
ISSN: | 0364-5134 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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