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Title: | Postmortem Interval and Diagnostic Performance of the Autopsy Methods |
Author: | Hurtado, Juan Carlos Quintó, Llorenç Castillo, Paola Carrilho, Carla Fernandes, Fabiola Jordao, Dercio Lovane, Lucilia Navarro, Mireia Casas, Isaac Bene, Rosa Nhampossa, Tacilta Santos Ritchie, Paula Bandeira, Sónia Sambo, Calvino Chicamba, Valeria Mocumbi, Sibone Jaze, Zara Mabota, Flora Ismail, Mamudo Rafik Lorenzoni, Cesaltina Guisseve, Assucena Rakislova, Natalia Marimon, Lorena Castrejón de Anta, Natalia Sanz, Ariadna Cossa, Anelsio Mandomando, Inácio Munguambe, Khátia Maixenchs, Maria Muñoz-Almagro, Carmen Macete, Eusebio Víctor Alonso, Pedro Vila Estapé, Jordi Bassat Orellana, Quique Menéndez, Clara Martínez Yoldi, Miguel Julián Ordi i Majà, Jaume |
Keywords: | Autòpsia Microbiologia sanitària Malalties infeccioses Salut pública Autopsy Sanitary microbiology Communicable diseases Public health |
Issue Date: | 31-Oct-2018 |
Publisher: | Nature Publishing Group |
Abstract: | Postmortem studies, including the complete diagnostic autopsy (CDA) and the minimally invasive autopsy (MIA), an innovative approach to post-mortem sampling and cause of death investigation, are commonly performed within 24 hours after death because the quality of the tissues deteriorates over time. This short timeframe may hamper the feasibility of the procedure. In this study, we compared the diagnostic performance of the two postmortem procedures when carried out earlier and later than 24 hours after death, as well as the impact of increasing postmortem intervals (PMIs) on the results of the microbiological tests in a series of 282 coupled MIA/CDA procedures performed at the Maputo Central Hospital in Mozambique between 2013 and 2015. 214 procedures were conducted within 24 hours of death (early autopsies), and 68 after 24 hours of death (late autopsies). No significant differences were observed in the number of non-conclusive diagnoses (2/214 [1%] vs. 1/68 [1%] p = 0.5645 for the CDA; 27/214 [13%] vs. 5/68 [7%] p = 0.2332 for the MIA). However, increasing PMIs were associated with a raise in the number of bacteria identified (rate: 1.014 per hour [95%CI: 1.002-1.026]; p = 0.0228). This increase was mainly due to rising numbers of bacteria of the Enterobacteriaceae family and Pseudomonas genus strains. Thus, performing MIA or CDA more than 24 hours after death can still render reliable diagnostic results, not only for non-infectious conditions but also for many infectious diseases, although, the contribution of Enterobacteriaceae and Pseudomonas spp. as etiological agents of infections leading to death may be overestimated. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-34436-1 |
It is part of: | Scientific Reports, 2018, vol. 8, num. 16112 |
URI: | http://hdl.handle.net/2445/129427 |
Related resource: | https://doi.org/10.1038/s41598-018-34436-1 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (ISGlobal) |
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