Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/129444
Title: Allostatic load and disordered white matter microstructure in overweight adults
Author: Ottino González, Jonatan
Jurado, Ma. Ángeles (María Ángeles)
García García, Isabel (Biòloga)
Segura i Fàbregas, Bàrbara
Marqués Iturria, Idoia
Sender Palacios, María José
Tor, Encarnació
Prats-Soteras, Xavier
Caldú i Ferrús, Xavier
Junqué i Plaja, Carme, 1955-
Pasternak, Ofer
Garolera i Freixa, Maite
Keywords: Cervell
Obesitat
Assaigs clínics
Sistema nerviós central
Estrès (Fisiologia)
Brain
Obesity
Clinical trials
Central nervous system
Stress (Physiology)
Issue Date: 26-Oct-2018
Publisher: Nature Publishing Group
Abstract: Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that in turn can damage the brain. However, the effects of the allostatic load on the central nervous system remain largely unknown. The current study aimed to assess the relationship between the allostatic load and the composition of whole-brain white matter tracts in overweight subjects. Additionally, we have also tested for grey matter changes regarding allostatic load increase. Thirty-one overweight-to-obese adults and 21 lean controls participated in the study. Our results showed that overweight participants presented higher allostatic load indexes. Such increases correlated with lower fractional anisotropy in the inferior fronto-occipital fasciculi and the right anterior corona radiata, as well as with grey matter reductions in the left precentral gyrus, the left lateral occipital gyrus, and the right pars opercularis. These results suggest that an otherwise healthy overweight status is linked to long-term biological changes potentially harmful to the brain.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-34219-8
It is part of: Scientific Reports, 2018, vol. 8, num. 15898
URI: http://hdl.handle.net/2445/129444
Related resource: https://doi.org/10.1038/s41598-018-34219-8
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Psicologia Clínica i Psicobiologia)

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