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Title: Impact of bronchiectasis on outcomes of hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease: A propensity matched analysis
Author: Crisafulli, Ernesto
Guerrero, Mónica
Ielpo, Antonella
Ceccato, Adrian
Huerta, Arturo
Gabarrús, Albert
Soler Porcar, Néstor
Chetta, Alfredo
Torres Martí, Antoni
Keywords: Malalties de l'aparell respiratori
Malalties pulmonars obstructives cròniques
Malalts hospitalitzats
Pronòstic mèdic
Respiratory diseases
Chronic obstructive pulmonary diseases
Hospital patients
Issue Date: 18-Jun-2018
Publisher: Nature Publishing Group
Abstract: The coexistence of both Chronic Obstructive Pulmonary Disease (COPD) and bronchiectasis (BE) define an emerging phenotype with a worse prognosis; however, data about these patients do not consider baseline characteristics as confounders. We evaluate the impact of BE on outcomes of hospitalized patients with acute exacerbation of COPD (AECOPD). We prospectively considered AECOPD patients, analysed using a propensity score matching (PSM) method. The outcomes included length of hospital stay, use of non-invasive and invasive mechanical ventilation, intensive care unit admission, and mortality up to 3-years. Out of the 449 patients enrolled, 160 had associated BE. AECOPD with BE were older, had lower body mass index and greater functional impairment and severity of symptoms than AECOPD without BE. After PSM, 91 patients were considered for each group and no significant differences were found for all baseline characteristics. In full cohort, the cumulative mortality rate, the survival time, the Kaplan-Meier survival curves and the risk of death were worse in AECOPD with BE in the follow-up of 6-months, 1-year and 3-years. After PSM, data on mortality were similar between AECOPD with and without BE. In conclusion, in AECOPD patients the presence of BE does not influence mortality in a long-term follow-up.
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It is part of: Scientific Reports, 2018, vol. 8, num. 9236
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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