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Title: Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: a nested case-control study
Author: Huang, Jiaqi
Zagai, Ulrika
Hallmans, Göran
Nyrén, Olof
Engstrand, Lars
Stolzenberg-Solomon, Rachael Z.
Duell, Eric J.
Overvad, Kim
Katzke, Verena
Kaaks, Rudolf
Jenab, Mazda
Park, Jing Young
Murillo, Raul
Trichopoulou, Antonia
Lagiou, Pagona
Bamia, Christina
Bradbury, Kathryn E.
Riboli, Elio
Aune, Dagfinn
Tsilidis, Konstantinos K.
Capellá, G. (Gabriel)
Agudo, Antonio
Krogh, Vittorio
Palli, Domenico
Panico, Salvatore
Weiderpass, Elisabete
Tjønneland, Anne
Olsen, Anja
Martínez, Begoña
Redondo Sánchez, Daniel
Chirlaque, María Dolores
Peeters, Petra H. M.
Regnér, Sara
Lindkvist, Björn
Naccarati, Alessio
Ardanaz, Eva
Dorronsoro, Miren
Larrañaga, Nerea
Rebours, Vinciane
Barré, Amélie
Keywords: Helicobacteri pilòric
Malalties cròniques
Càncer de pàncrees
Estudi de casos
Helicobacter pylori
Chronic diseases
Pancreas cancer
Case studies
Issue Date: 15-Apr-2017
Publisher: Wiley
Abstract: The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR = 0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR = 1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR = 0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR = 1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR = 5.66; 95% CI: 1.59, 20.19, p value for interaction < 0.01). Our findings provided evidence supporting the null association between H. pylori infection and pancreatic cancer risk in western European populations. However, the suggested association between chronic corpus atrophic gastritis and pancreatic cancer risk warrants independent verification in future studies, and, if confirmed, further studies on the underlying mechanisms.
Note: Versió postprint del document publicat a:
It is part of: International Journal of Cancer, 2017, vol. 140, num. 8, p. 1727-1735
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ISSN: 0020-7136
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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