Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/130527
Title: Preventive effect of a synbiotic combination of galacto- and fructooligosaccharides mixture with Bifidobacterium breve M-16V in a model of multiple rotavirus infections
Author: Rigo-Adrover, Mar
van Limpt, Kees
Knipping, K.
Garssen, J.
Knol, J.
Costabile, Adele
Franch i Masferrer, Àngels
Castell, Margarida
Pérez-Cano, Francisco J.
Keywords: Prebiòtics
Probiòtics
Malalties intestinals
Prebiotics
Probiotics
Intestinal diseases
Issue Date: 2018
Publisher: Frontiers Media
Abstract: Rotavirus (RV) causes morbidity and mortality among infants worldwide, and there is evidence that probiotics and prebiotics can have a positive influence against infective processes such as that due to RV. The aim of this study was to evidence a preventive role of one prebiotic mixture (of short-chain galactooligosaccharide/long-chain fructooligosaccharide), the probiotic Bifidobacterium breve M-16V and the combination of the prebiotic and the probiotic, as a synbiotic, in a suckling rat double-RV infection model. Hyperimmune bovine colostrum was used as protection control. The first infection was induced with RV SA11 and the second one with EDIM. Clinical variables and immune response were evaluated after both infections. Dietary interventions ameliorated clinical symptoms after the first infection. The prebiotic and the synbiotic significantly reduced viral shedding after the first infection, but all the interventions showed higher viral load than in the RV group after the second infection. All interventions modulated ex vivo antibody and cytokine production, gut wash cytokine levels and small intestine gene expression after both infections. In conclusion, a daily supplement of the products tested in this preclinical model is highly effective in preventing RV-induced diarrhea but allowing the boost of the early immune response for a future immune response against reinfection, suggesting that these components may be potential agents for modulating RV infection in infants. Keywords: prebiotic, probiotic, synbiotic, rotavirus, FOS, GOS, Bifidobacterium breve
Note: Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2018.01318
It is part of: Frontiers in Immunology, 2018, vol. 9, p. 1318
URI: http://hdl.handle.net/2445/130527
Related resource: https://doi.org/10.3389/fimmu.2018.01318
ISSN: 1664-3224
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

Files in This Item:
File Description SizeFormat 
686426.pdf3.17 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons