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Title: Purging behavior modulates the relationships of hormonal and behavioral parameters in women with eating disorders
Author: Grasa Martínez, Maria del Mar
Villarreal, Laura
Granero, Roser
Vilà Baños, Ruth
Penelo, Eva
Agüera, Zaida
Jiménez-Murcia, Susana
Romero Romero, María del Mar
Menchón Magriñá, José Manuel
Remesar Betlloch, Xavier
Fernández Aranda, Fernando
Alemany, Marià, 1946-
Keywords: Trastorns de la conducta alimentària
Eating disorders
Issue Date: 14-May-2013
Publisher: Karger
Abstract: Background/aims: There is ample consensus that there is a neurophysiological basis for the eating disorders (ED). Traits of personality translate into behavioural traits, purging being a well defined transversal example. Direct implication of steroid hormones on ED has been seldom studied, despite their effects on behaviour. Methods: After psychological interview analysis 57 ED female patients (31 purgative and 26 non-purgative), and 17 female controls were studied. Metabolic parameters and analysis of androgen, estrogen and glucocorticoid hormones were determined in parallel to the psychopathological profile (EDI-2 and SCL-90-R) and anthropometric measurements. Results: Psychometric tests showed clear differences between ED and controls, but there were few hormonal-metabolic significant differences. In purgative ED there were repeated (significant) positive correlations with CBG, and negative with SHBG, versus eating and general psychopathology. In non-purging, there were positive correlations for deoxycortisol, free fatty acids, albumin and negative for aspartate aminotransferase and psychopathological traits. Conclusion: The data hint at CBG/corticosteroids and sexual hormones/SHBG to be involved in purging behaviour and its psychopathology and severity scores. Correlations of selected psychometric data and the CBG/SHBG levels in purging may eventually result in clinical markers. This approach may provide additional clues for understanding the pathogenesis of the ED.
Note: Versió postprint del document publicat a:
It is part of: Neuropsychobiology, 2013, vol. 67, num. 4, p. 230-240
Related resource:
ISSN: 0302-282X
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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