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Title: Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study
Author: Gómez Acebo, Inés
Dierssen Sotos, Trinidad
Palazuelos, Camilo
Fernández Navarro, Pablo
Castaño Vinyals, Gemma
Alonso Molero, Jéssica
Urtiaga, Carmen
Fernández Villa, Tania
Ardanaz, Eva
Riva del Fresno, Manuel
Molina Barceló, Ana
Jiménez Moleón, José Juan
García Martinez, Lidia
Amiano, Pilar
Rodriguez Cundin, Paz
Moreno Aguado, Víctor
Pérez Gómez, Beatriz
Aragonés, Nuria
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
Keywords: Càncer de mama
Càncer de pròstata
Breast cancer
Prostate cancer
Issue Date: 14-Aug-2018
Publisher: Public Library of Science (PLoS)
Abstract: INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2018, vol. 13, num. 8, p. e0201750
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Ciències Clíniques)

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