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Title: Abnormalities in gray matter volume in patients with borderline personality disorder and their relation to lifetime depression: A VBM study.
Author: Aguilar Ortiz, Salvatore
Salgado Pineda, Pilar
Marco Pallarés, Josep
Pascual, Juan C.
Vega, Daniel
Soler, Joaquim
Brunel, Cristina
Martin Blanco, Ana
Soto, Ángel
Ribas, Joan
Maristany, Teresa
Sarró, Salvador
Salvador, Raymond
Rodríguez Fornells, Antoni
Pomarol Clotet, Edith
McKenna, Peter J.
Keywords: Depressió psíquica
Trastorns de la personalitat
Hipocamp (Cervell)
Lòbul frontal
Mental depression
Personality disorders
Hippocampus (Brain)
Frontal lobe
Issue Date: 21-Feb-2018
Publisher: Public Library of Science (PLoS)
Abstract: Background Structural imaging studies of borderline personality disorder (BPD) have found regions of reduced cortical volume, but these have varied considerably across studies. Reduced hippocampus and amygdala volume have also been a regular finding in studies using conventional volumetric measurement. How far comorbid major depression, which is common in BPD and can also affect in brain structure, influences the findings is not clear. Methods Seventy-six women with BPD and 76 matched controls were examined using whole-brain voxel-based morphometry (VBM). The hippocampus and amygdala were also measured, using both conventional volume measurement and VBM within a mask restricted to these two subcortical structures. Lifetime history of major depression was assessed using structured psychiatric interview. Results At a threshold of p = 0.05 corrected, the BPD patients showed clusters of volume reduction in the dorsolateral prefrontal cortex bilaterally and in the pregenual/subgenual medial frontal cortex. There was no evidence of volume reductions in the hippocampus or amygdala, either on conventional volumetry or using VBM masked to these regions. Instead there was evidence of right-sided enlargement of these structures. No significant structural differences were found between patients with and without lifetime major depression. Conclusions According to this study, BPD is characterized by a restricted pattern of cortical volume reduction involving the dorsolateral frontal cortex and the medial frontal cortex, both areas of potential relevance for the clinical features of the disorder. Previous findings concerning reduced hippocampus and amygdala volume in the disorder are not supported. Brain structural findings in BPD do not appear to be explainable on the basis of history of associated lifetime major depression.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2018, vol. 13, num. 2, p. e0191946
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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