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Title: A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma
Author: Armangué, Thaís
Titulaer, Maarten J.
Sabater, Lidia
Pardo Moreno, Javier
Gresa Arribas, Nuria
Barbero Bordallo, Natalia
Kelley, Gordon R.
Kyung-Ha, Noh
Takeda, Akitoshi
Nagao, Takahiro
Takahashi, Yukitoshi
Lizcano, Angélica
Carr, Aisling S.
Graus Ribas, Francesc
Dalmau Obrador, Josep
Keywords: Teratoma
Tumors cerebrals
Brain tumors
Issue Date: 24-Apr-2013
Publisher: Wiley-Liss
Abstract: Among 249 patients with teratoma‐associated encephalitis, 211 had N‐methyl‐D‐aspartate receptor antibodies and 38 were negative for these antibodies. Whereas antibody‐positive patients rarely developed prominent brainstem-cerebellar symptoms, 22 (58%) antibody‐negative patients developed a brainstem-cerebellar syndrome, which in 45% occurred with opsoclonus. The median age of these patients was 28.5 years (range = 12-41), 91% were women, and 74% had full recovery after therapy and tumor resection. These findings uncover a novel phenotype of paraneoplastic opsoclonus that until recently was likely considered idiopathic or postinfectious. The triad of young age (teenager to young adult), systemic teratoma, and high response to treatment characterize this novel brainstem-cerebellar syndrome.
Note: Versió postprint del document publicat a:
It is part of: Annals of Neurology, 2013, vol. 75, num. 3, p. 435-441
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ISSN: 0364-5134
Appears in Collections:Articles publicats en revistes (Medicina)

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