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http://hdl.handle.net/2445/130801
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DC Field | Value | Language |
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dc.contributor.author | Càmara, Jordi | - |
dc.contributor.author | Marimón, José María | - |
dc.contributor.author | Cercenado, Emilia | - |
dc.contributor.author | Larrosa, Nieves | - |
dc.contributor.author | Quesada, María Dolores | - |
dc.contributor.author | Fontanals, Dionísia | - |
dc.contributor.author | Cubero, Meritxell | - |
dc.contributor.author | Pérez Trallero, Emilio | - |
dc.contributor.author | Fenoll, Asunción | - |
dc.contributor.author | Liñares Louzao, Josefina | - |
dc.contributor.author | Ardanuy Tisaire, María Carmen | - |
dc.date.accessioned | 2019-03-22T13:21:45Z | - |
dc.date.available | 2019-03-22T13:21:45Z | - |
dc.date.issued | 2017-04-06 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/130801 | - |
dc.description.abstract | A prospective laboratory-based multicenter study that collected all adult invasive pneumococcal disease (IPD) episodes from 6 Spanish hospitals before (2008-2009) and after (2012-2013). The 13-valent pneumococcal conjugate vaccine (PCV13) licensure was conducted in order to analyze the impact of PCV13 introduction for children on adult IPD. A total of 1558 IPD episodes were detected. The incidence of IPD decreased significantly in the second period by-33.9% (95% CI,-40.3% to-26.8%). IPD due to PCV7 serotypes (-52.7%; 95% CI,-64.2% to-37.5%) and to PCV13 additional serotypes (-55.0% 95% CI, -62.0% to-46.7%) significantly decreased whereas IPD due to non-PCV13 serotypes remained stable (1.0% 95% CI,-12.9% to 17.2%). IPD due to all PCV13 additional serotypes significantly declined with the exception of serotype 3 (-11.3%; 95% CI-35.0% to 21.1%). IPD due to two non-PCV13 serotypes varied: serotype 6C that rose (301.6%; 95% CI, 92.7% to 733.3%, p<0.001), related to the expansion of ST386(6C), and serotype 8 that decreased (-34.9%, 95% CI,-57.1 to-1.2, p = 0.049), related to a decline of the ST63(8). The recombinant clone ST6521(11A) (variant of ST156(9V)) increased in frequency. The decrease of serotype 19A IPD was linked to a fall in those antibiotic susceptible clones. In the last period, rates of penicillin-and cefotaxime-resistance remained under 10% and 4%, respectively. Adult IPD decreased after the PCV13 introduction in Spain due to herd protection. The spread of multidrug resistant clones (ST386(6C), ST6521(11A)) related to non-PCV13 serotypes needs further surveillance. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0175224 | - |
dc.relation.ispartof | PLoS One, 2017, vol. 12, num. 4, p. e0175224 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0175224 | - |
dc.rights | cc-by (c) Càmara, Jordi et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Pneumònia | - |
dc.subject.classification | Vacunes | - |
dc.subject.classification | Espanya | - |
dc.subject.classification | Infeccions per pneumococs | - |
dc.subject.other | Pneumonia | - |
dc.subject.other | Vaccines | - |
dc.subject.other | Spain | - |
dc.subject.other | Pneumococcal Infections | - |
dc.title | Decrease of invasive pneumococcal disease (IPD) in adults after introduction of pneumococcal 13-valent conjugate vaccine in Spain | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 685197 | - |
dc.date.updated | 2019-03-22T13:21:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28384325 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Patologia i Terapèutica Experimental) |
Files in This Item:
File | Description | Size | Format | |
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685197.pdf | 1.11 MB | Adobe PDF | View/Open |
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