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DC Field | Value | Language |
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dc.contributor.author | Gambato, Martina | - |
dc.contributor.author | Caro Pérez, Noelia | - |
dc.contributor.author | González, Patricia | - |
dc.contributor.author | Cañete, Núria | - |
dc.contributor.author | Mariño, Zoe | - |
dc.contributor.author | Lens, Sabela | - |
dc.contributor.author | Bonacci, Martín | - |
dc.contributor.author | Bartrés, Concepció | - |
dc.contributor.author | Sánchez Tapias, José M. (José María) | - |
dc.contributor.author | Carrión, José A. | - |
dc.contributor.author | Forns, Xavier | - |
dc.contributor.author | Juan, Manel | - |
dc.contributor.author | Pérez del Pulgar Gallart, Sofía | - |
dc.contributor.author | Londoño, María Carlota | - |
dc.date.accessioned | 2019-03-26T13:35:30Z | - |
dc.date.available | 2019-03-26T13:35:30Z | - |
dc.date.issued | 2016-11-18 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/130926 | - |
dc.description.abstract | Real-life data showed an increased incidence of bacterial infections in patients with advanced liver disease receiving a protease inhibitor (PI)-containing antiviral regimen against hepatitis C (HCV). However, the causes of this event are unknown. We hypothesized that PIs might impair innate immune responses through the inhibition of proteases participating in the anti-bacterial functions of neutrophils and monocytes. The aims of the study were to assess phagocytic and oxidative burst capacity in neutrophils and monocytes obtained from patients receiving a PI containing-antiviral regimen, and to determine cytokine secretion after neutrophil stimulation with flagellin. Forty patients with chronic HCV (80% with cirrhosis) were enrolled in the study, 28 received triple therapy (Group A) with pegylated-interferon and ribavirin for 4 weeks followed by the addition of a PI (telaprevir, boceprevir or simeprevir), and 12 patients received an interferon-free regimen (Group B) with simeprevir and sofosbuvir. Phagocytosis and oxidative burst capacity were analyzed by flow cytometry at baseline, week 4, and week 8 of therapy. In neutrophils from Group A patients, oxidative burst rate and oxidative enzymatic activity per cell significantly decreased throughout the study period (p = 0.014 and p = 0.010, respectively). Pairwise comparisons showed a decrease between baseline and week 4 and 8 of therapy. No differences were observed after the introduction of the PI. The oxidative enzymatic activity per cell in monocytes significantly decrease during the study period (p = 0.042) due to a decrease from baseline to week 8 of therapy (p = 0.037) in patients from Group A. None of these findings were observed in Group B patients. Cytokine secretion did not significantly change during the study in both groups. In conclusion, our data suggest that the use interferon (rather than the PI) has a deleterious effect on neutrophil and monocyte phagocytic and oxidative burst capacity in this cohort of patients with HCV-related advanced liver fibrosis. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0166631 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 11, p. e0166631 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0166631 | - |
dc.rights | cc-by (c) Gambato, Martina et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Hepatitis C | - |
dc.subject.classification | Malalties cròniques | - |
dc.subject.classification | Interferó | - |
dc.subject.classification | Cirrosi hepàtica | - |
dc.subject.other | Hepatitis C | - |
dc.subject.other | Chronic diseases | - |
dc.subject.other | Interferon | - |
dc.subject.other | Hepatic cirrhosis | - |
dc.title | Neutrophil and Monocyte Function in Patients with Chronic Hepatitis C Undergoing Antiviral Therapy with Regimens Containing Protease Inhibitors with and without Interferon | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 686464 | - |
dc.date.updated | 2019-03-26T13:35:30Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27861593 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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