Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/131021
Title: Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models
Author: Lutfi, Esmail
Babin, Patrick J.
Gutiérrez Fruitós, Joaquín
Capilla Campos, Encarnación
Navarro Álvarez, Isabel
Keywords: Productes naturals
Compostos bioactius vegetals
Obesitat
Peix zebra
Natural products
Plant bioactive compounds
Obesity
Zebra danio
Issue Date: 1-Jun-2017
Publisher: Public Library of Science (PLoS)
Abstract: Some natural products, known sources of bioactive compounds with a wide range of properties, may have therapeutic values in human health and diseases, as well as agronomic applications. The effect of three compounds of plant origin with well-known dietary antioxidant properties, astaxanthin (ATX), caffeic acid (CA) and hydroxytyrosol (HT), on zebrafish (Danio rerio) larval adiposity and rainbow trout (Onchorynchus mykiss) adipocytes was assessed. The zebrafish obesogenic test (ZOT) demonstrated the anti-obesogenic activity of CA and HT. These compounds were able to counteract the obesogenic effect produced by the peroxisome proliferator-activated receptor gamma (PPAR.) agonist, rosiglitazone (RGZ). CA and HT suppressed RGZ-increased PPAR. protein expression and lipid accumulation in primary-cultured rainbow trout adipocytes. HT also significantly reduced plasma triacylglycerol concentrations, as well as mRNA levels of the fasn adipogenic gene in the adipose tissue of HT-injected rainbow trout. In conclusion, in vitro and in vivo approaches demonstrated the anti-obesogenic potential of CA and HT on teleost fish models that may be relevant for studying their molecular mode of action. Further studies are required to evaluate the effect of these bioactive components as food supplements for modulating adiposity in farmed fish.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0178833
It is part of: PLoS One, 2017, vol. 12, num. 6, p. e0178833
URI: http://hdl.handle.net/2445/131021
Related resource: https://doi.org/10.1371/journal.pone.0178833
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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