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http://hdl.handle.net/2445/131078
Title: | Intercalative DNA binding of the marine anticancer drug variolin B |
Author: | Canals, Albert Arribas Bosacoma, Raquel Albericio Palomera, Fernando Álvarez Domingo, Mercedes Aymamí, Joan Coll, Miquel |
Keywords: | Alcaloides Medicaments antineoplàstics ADN Medicaments antivírics Alkaloids Antineoplastic agents DNA Antiviral agents |
Issue Date: | 4-Jan-2017 |
Publisher: | Nature Publishing Group |
Abstract: | Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/srep39680 |
It is part of: | Scientific Reports, 2017, vol. 7, num. 39680 |
URI: | http://hdl.handle.net/2445/131078 |
Related resource: | https://doi.org/10.1038/srep39680 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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