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http://hdl.handle.net/2445/131299
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DC Field | Value | Language |
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dc.contributor.author | Efsen, Anne Marie W. | - |
dc.contributor.author | Schultze, Anna | - |
dc.contributor.author | Miller, Robert F. | - |
dc.contributor.author | Panteleev, Alexander | - |
dc.contributor.author | Skrahin, Aliaksandr | - |
dc.contributor.author | Podlekareva, Daria N. | - |
dc.contributor.author | Miró Meda, José M. | - |
dc.contributor.author | Girardi, Enrico | - |
dc.contributor.author | Furrer, Hansjakob | - |
dc.contributor.author | Losso, Marcelo H. | - |
dc.contributor.author | Toibaro, Javier | - |
dc.contributor.author | Caylà i Buqueras, Joan A. | - |
dc.contributor.author | Mocroft, Amanda | - |
dc.contributor.author | Lundgren, Jens D. | - |
dc.contributor.author | Kirk, Ole | - |
dc.contributor.author | Post, Frank A. | - |
dc.contributor.author | Manzardo, Christian | - |
dc.contributor.author | Ligero, M. C. | - |
dc.contributor.author | González, J. | - |
dc.contributor.author | HIV study in EuroCoord | - |
dc.date.accessioned | 2019-04-03T14:18:23Z | - |
dc.date.available | 2019-04-03T14:18:23Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 0163-4453 | - |
dc.identifier.uri | http://hdl.handle.net/2445/131299 | - |
dc.description.abstract | Objectives: Mortality among HIV patients with tuberculosis (TB) remains high in Eastern Europe (EE), but details of TB and HIV management remain scarce. Methods: In this prospective study, we describe the TB treatment regimens of patients with multi-drug resistant (MDR) TB and use of antiretroviral therapy (ART). Results: A total of 105 HIV-positive patients had MDR-TB (including 33 with extensive drug resistance) and 130 pan-susceptible TB. Adequate initial TB treatment was provided for 8% of patients with MDR-TB compared with 80% of those with pan-susceptible TB. By twelve months, an estimated 57.3% (95%CI 41.5-74.1) of MDR-TB patients had started adequate treatment. While 67% received ART, HIV-RNA suppression was demonstrated in only 23%. Conclusions: Our results show that internationally recommended MDR-TB treatment regimens were infrequently used and that ART use and viral suppression was well below the target of 90%, reflecting the challenging patient population and the environment in which health care is provided. Urgent improvement of management of patients with TB/HIV in EE, in particular for those with MDR-TB, is needed and includes widespread access to rapid TB diagnostics, better access to and use of second-line TB drugs, timely ART initiation with viral load monitoring, and integration of TB/HIV care. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.jinf.2017.10.007 | - |
dc.relation.ispartof | Journal of Infection, 2018, vol. 76, num. 1, p. 44-54 | - |
dc.relation.uri | https://doi.org/10.1016/j.jinf.2017.10.007 | - |
dc.rights | cc-by-nc-nd (c) The British Infection Association, 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Infeccions per VIH | - |
dc.subject.classification | Tuberculosi | - |
dc.subject.other | HIV infections | - |
dc.subject.other | Tuberculosis | - |
dc.title | Management of MDR-TB in HIV co-infected patients in Eastern Europe: Results from the TB: HIV study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 677524 | - |
dc.date.updated | 2019-04-03T14:18:23Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/260694/EU//EUROCOORD | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29061336 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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677524.pdf | 1.34 MB | Adobe PDF | View/Open |
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