Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/131923
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DC Field | Value | Language |
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dc.contributor.author | Mol, Eva de | - |
dc.contributor.author | Fenwick, R. Bryn | - |
dc.contributor.author | Martínez Cristóbal, Paula | - |
dc.contributor.author | Buzón Redorta, Víctor | - |
dc.contributor.author | Szulc, Elzbieta Maria | - |
dc.contributor.author | Frigolé Vivas, Marta | - |
dc.contributor.author | Masín, Mariela | - |
dc.contributor.author | García, Jesús | - |
dc.contributor.author | Bertoncini, Carlos W. | - |
dc.contributor.author | Estébanez Perpiñá, Eva | - |
dc.contributor.author | McEwan, Iain J. | - |
dc.contributor.author | Nebreda, Àngel R. | - |
dc.contributor.author | Salvatella i Giralt, Xavier | - |
dc.contributor.author | Sanza, Claudio di | - |
dc.contributor.author | Hunter, Irene | - |
dc.contributor.author | Brun Heath, Isabelle | - |
dc.contributor.author | Fabritiis, Gianni di | - |
dc.date.accessioned | 2019-04-09T11:51:39Z | - |
dc.date.available | 2019-04-09T11:51:39Z | - |
dc.date.issued | 2018-01-02 | - |
dc.identifier.issn | 0969-2126 | - |
dc.identifier.uri | http://hdl.handle.net/2445/131923 | - |
dc.description.abstract | The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The mechanistic basis of these interactions is poorly understood due to the intrinsically disordered nature of the transactivation domain of the androgen receptor and the generally transient nature of the protein-protein interactions that trigger transcription. Here, we identify a motif of the transactivation domain that contributes to transcriptional activity by recruiting the C-terminal domain of subunit 1 of the general transcription regulator TFIIF. These findings provide molecular insights into the regulation of androgen receptor function and suggest strategies for treating castration-resistant prostate cancer. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.str.2017.11.007 | - |
dc.relation.ispartof | Structure, 2018, vol. 11, num. 9, p. 2499-2505 | - |
dc.relation.uri | https://doi.org/10.1016/j.str.2017.11.007 | - |
dc.rights | cc-by-nc-nd (c) Elsevier Ltd, 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Càncer de pròstata | - |
dc.subject.classification | Receptors d'hormones | - |
dc.subject.classification | Andrògens | - |
dc.subject.classification | Terapèutica | - |
dc.subject.other | Prostate cancer | - |
dc.subject.other | Hormone receptors | - |
dc.subject.other | Androgens | - |
dc.subject.other | Therapeutics | - |
dc.title | Regulation of androgen receptor activity by transient interactions of its transactivation domain with general transcription regulators | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 674927 | - |
dc.date.updated | 2019-04-09T11:51:40Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/648201/EU//CONCERT | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29225078 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) Publicacions de projectes de recerca finançats per la UE |
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File | Description | Size | Format | |
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674927.pdf | 817.75 kB | Adobe PDF | View/Open |
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