Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/132153
Title: The associations of earlier trauma exposures and history of mental disorders with PTSD after subsequent traumas
Author: Kessler, Ronald C.
Aguilar Gaxiola, Sergio A.
Alonso, Jordi
Bromet, Evelyn J.
Gureje, Oye
Karam, Elie George
Koenen, Karestan C.
Lee, Soon Yeun
Liu, Howard
Pennell, Brandi
Petukhova, Maria Vladimirovna
Sampson, Nancy A.
Shahly, Victoria L.
Stein, Dan J.
Atwoli, Lukoye
Borges, Guilherme
Bunting, Brendan
Girolamo, Giovanni de
Gluzman, Semyon F.
Haro Abad, Josep Maria
Hinkov, Hristo Ruskov
Kawakami, Norito
Kovess Masfety, Viviane
Navarro Mateu, Fernando
Posada Villa, Jose A.
Scott, Kate Margaret
Shalev, Arieh Y.
Ten Have, Margreet
Guerrero Torres, Yolanda
Viana, Maria Carmen
Zaslavsky, Alan M.
Keywords: Malalties mentals
Traumes psíquics
Trastorn per estrès posttraumàtic
Mental illness
Psychic trauma
Post-traumatic stress disorder
Issue Date: 19-Sep-2017
Publisher: Nature Publishing Group
Abstract: Abstract Although earlier trauma exposure is known to predict posttraumatic stress disorder (PTSD) after subsequent traumas, it is unclear whether this association is limited to cases where the earlier trauma led to PTSD. Resolution of this uncertainty has important implications for research on pretrauma vulnerability to PTSD. We examined this issue in the World Health Organization (WHO) World Mental Health (WMH) Surveys with 34 676 respondents who reported lifetime trauma exposure. One lifetime trauma was selected randomly for each respondent. DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) PTSD due to that trauma was assessed. We reported in a previous paper that four earlier traumas involving interpersonal violence significantly predicted PTSD after subsequent random traumas (odds ratio (OR)=1.3-2.5). We also assessed 14 lifetime DSM-IV mood, anxiety, disruptive behavior and substance disorders before random traumas. We show in the current report that only prior anxiety disorders significantly predicted PTSD in a multivariate model (OR=1.5-4.3) and that these disorders interacted significantly with three of the earlier traumas (witnessing atrocities, physical violence victimization and rape). History of witnessing atrocities significantly predicted PTSD after subsequent random traumas only among respondents with prior PTSD (OR=5.6). Histories of physical violence victimization (OR=1.5) and rape after age 17 years (OR=17.6) significantly predicted only among respondents with no history of prior anxiety disorders. Although only preliminary due to reliance on retrospective reports, these results suggest that history of anxiety disorders and history of a limited number of earlier traumas might usefully be targeted in future prospective studies as distinct foci of research on individual differences in vulnerability to PTSD after subsequent traumas.
Note: Versió postprint del document publicat a: https://doi.org/10.1038/mp.2017.194
It is part of: Molecular Psychiatry, 2017, vol. 23, num. 9, p. 1-8
URI: http://hdl.handle.net/2445/132153
Related resource: https://doi.org/10.1038/mp.2017.194
ISSN: 1359-4184
Appears in Collections:Articles publicats en revistes (Medicina)

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