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http://hdl.handle.net/2445/132634| Title: | Stereoselective synthesis of protected peptides containing an anti β‐Hydroxy tyrosine |
| Author: | Fernandez-Valparis, Javier Romea, Pedro Urpí Tubella, Fèlix |
| Keywords: | Pèptids Estereoquímica Quiralitat Peptides Stereochemistry Chirality |
| Issue Date: | 19-Mar-2019 |
| Publisher: | Wiley-VCH |
| Abstract: | Protected peptides containing an anti b-hydroxy tyrosine are synthesized in a straightforward and highly efficient manner through the direct and stereoselective addition of N-azidoacetyl-4-isopropyl-1,3-thiazolidine-2-thione to dialkyl acetals catalyzed by a nickel(II) complex, the forging of an amide bond by removal of the chiral auxiliary with an amino ester, and final coupling with a third amino acid. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1002/ejoc.201900301 |
| It is part of: | European Journal of Organic Chemistry, 2019, vol. 2019, num. 16, p. 2745-2752 |
| URI: | http://hdl.handle.net/2445/132634 |
| Related resource: | https://doi.org/10.1002/ejoc.201900301 |
| ISSN: | 1434-193X |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 689924.pdf | 515.04 kB | Adobe PDF | View/Open |
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