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Title: Targeting prohibitins induces apoptosis in acute myeloid leukemia cells
Author: Pomares, Helena
Palmeri, Claudia Mariela
Iglesias i Serret, Daniel
Moncunill Massaguer, Cristina
Saura-Esteller, José
Núñez-Vázquez, Sonia
Gamundi, Enric
Arnan, Montserrat
Preciado Gallego, Sara
Albericio Palomera, Fernando
Lavilla Grífols, Rodolfo
Pons i Irazazábal, Gabriel
González Barca, Eva
Cosialls Castel, Ana Mª
Gil i Santano, Joan
Keywords: Càncer
Issue Date: 10-Feb-2016
Publisher: Impact Journals
Abstract: Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins (PHBs). In this study, the pro-apoptotic effect of fluorizoline was assessed in two cell lines and 21 primary samples from patients with debut of acute myeloid leukemia (AML). Fluorizoline induced apoptosis in AML cells at concentrations in the low micromolar range. All primary samples were sensitive to fluorizoline irrespectively of patients' clinical or genetic features. In addition, fluorizoline inhibited the clonogenic capacity and induced differentiation of AML cells. Fluorizoline increased the mRNA and protein levels of the pro-apoptotic BCL-2 family member NOXA both in cell lines and primary samples analyzed. These results suggest that targeting PHBs could be a new therapeutic strategy for AML
Note: Reproducció del document publicat a:
It is part of: Oncotarget, 2016, vol. 7, num. 40, p. 64987-65000
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ISSN: 1949-2553
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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