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Title: Bone marrow characterization in COPD: a multi-level network analysis
Author: Toledo Pons, Nuria
Noell, Guillaume
Jahn, Andreas
Iglesias, Amanda
Duran, Maria Antonia
Iglesias, Julio
Rios, Angel
Scrimini, Sergio
Faner, Rosa
Gigirey, Orlando
Agustí García-Navarro, Àlvar
Cosío, Borja G.
Keywords: Malalties pulmonars obstructives cròniques
Medul·la òssia
Assaigs clínics
Chronic obstructive pulmonary diseases
Bone marrow
Clinical trials
Issue Date: 15-Jun-2018
Publisher: BioMed Central
Abstract: BACKGROUND: Bone marrow (BM) produces hematopoietic and progenitor cells that contribute to distant organ inflammation and repair. Chronic obstructive pulmonary disease (COPD) is characterized by defective lung repair. Yet, BM composition has not been previously characterized in COPD patients. METHODS: In this prospective and controlled study, BM was obtained by sternum fine-needle aspiration in 35 COPD patients and 25 healthy controls (10 smokers and 15 never-smokers). BM cell count and immunophenotype were determined by microscopy and flow cytometry, respectively. Circulating inflammatory (C-reactive protein, IL-6, IL-8) and repair markers (HGF, IGF, TGF-β, VEGF) were quantified by ELISA. Results were integrated by multi-level network correlation analysis. RESULTS: We found that: (1) there were no major significant pair wise differences between COPD patients and controls in the BM structural characteristics; (2) multi-level network analysis including patients and controls identifies a relation between immunity, repair and lung function not previously described, that remains in the COPD network but is absent in controls; and (3) this novel network identifies eosinophils as a potential mediator relating immunity and repair, particularly in patients with emphysema. CONCLUSIONS: Overall, these results suggest that BM is activated in COPD with impaired repair capacity in patients with more emphysema and/or higher circulating eosinophils.
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It is part of: Respiratory Research, 2018, vol. 19, num. 1, p. 118-127
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ISSN: 1465-993X
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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